Kostas Zisimos

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BACKGROUND L-arginine, the substrate for endothelial nitric oxide synthase, is essential for normal endothelial function. Aim of the present study was to investigate in healthy smokers the effect of a short-term daily L-arginine administration on vascular function. METHODS We studied the effect of a 3-day oral administration of L-arginine in 10 healthy(More)
BACKGROUND Studies indicate that myeloperoxidase (MPO) is associated with disease progression and severity in heart failure (HF), while it may provide a mechanistic link between inflammation and adverse cardiac remodeling. The mechanisms that regulate MPO are unclear, while it is unknown whether specific treatments such as HMG-CoA reductase inhibitors and(More)
BACKGROUND Dobutamine stress contrast echo (DSCE) has a well-established prognostic value in the context of coronary artery disease (CAD). However, data regarding its prognostic capability separately in men and women are scarce. The aim of the current study was to assess gender-related differences in the prognostic performance of DSCE. METHODS DSCE was(More)
BACKGROUND Atrial fibrillation has been associated with increased oxidative stress, elevated inflammatory status and endothelial dysfunction. However, the underlying mechanisms regulating the expression of inflammatory markers or oxidative stress status are unclear. We searched for clinical determinants of oxidative stress status, endothelial function and(More)
BACKGROUND Smoking is associated with endothelial dysfunction and increased inflammatory status. The amino acid L-arginine, improves endothelial function in patients with cardiovascular risk factors. We investigated the effect of L-arginine on vascular function and inflammatory process in healthy smokers at rest and after acute smoking. METHODS We studied(More)
BACKGROUND Multifocal atrial tachycardias confer an adverse prognosis in hospitalized patients. We assessed the prognostic impact of multifocal atrial rhythms (MARs-either chaotic atrial rhythm or multifocal atrial tachycardia/bradycardia) in very elderly outpatients. METHODS One hundred ten subjects aged 60-74 years, 112 aged 75-89 years, and 61 over 90(More)
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