Kostas Saranteas

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A combination of analytical and statistical methods is used to improve a tablet coating process guided by quality by design (QbD) principles. A solid dosage form product was found to intermittently exhibit bad taste. A suspected cause was the variability in coating thickness which could lead to the subject tasting the active ingredient in some tablets. A(More)
OBJECTIVE The essential aim of this article is to develop effective methods for improving the flow properties of active pharmaceutical ingredients (APIs) without requiring particle size or shape modification. METHODS The 'formulation' approach used here focuses on enhancing flow properties of three chemically different drug powders (micronized(More)
A laser-induced breakdown spectroscopy-based analytical methodology is developed to study tablet coating variability in pharmaceutical tablets. The method quantifies the amount of coating on a tablet by assigning an average coating thickness score to it. When tested using samples with different amounts of coating, the coating thickness scores showed direct(More)
The present research work aims to demonstrate the effectiveness of the new methodology of Design of Dynamic Experiments (DoDE) in optimizing an important pharmaceutical reaction. An easily developed response surface model (RSM) is used instead of a hard to develop knowledge-driven process model. The DoDE approach allows the experimenter to introduce dynamic(More)
This paper addresses the estimation of fractional composition of two diastereomers during crystallization. The estimation is obtained through a Partial Least Square (PLS) model that utilizes on-line Raman spectroscopy and additional process information such as temperature and slurry density. Several PLS models are developed that incorporate conditions that(More)
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