Kostas Floros

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We consider the problem of allocating bandwidth between two endpoints of a backbone network so that no parts of the network are unnecessarily loaded. We formulate the problem as lexicographic optimization and develop algorithms for its solution. The solution consists of: 1) identifying a cut in the network where the optimal load can be determined on all the(More)
Apoptotic cell death is a highly regulated process, which plays a crucial role in many biological events. Etoposide is an antineoplastic drug, which targets the DNA unwinding enzyme, topoisomerase II. The aim of the present research approach to investigate the expression of the apoptosis-related genes BCL2 (Bcl-2), FAS, Caspase-3, BAX and the new member(More)
The anti-apoptotic molecule BCL2 delays cell-cycle entry from quiescence. We have recently cloned a new member of the BCL2 family of apoptosis-related genes, BCL2L12. In the present study, the expression of BCL2 and BCL2L12 genes during cisplatin-induced apoptosis in HL-60 leukemic cells was investigated. The kinetics of apoptosis induction and cell(More)
The BCL2 family of genes (B-cell CLL/lymphoma 2; Bcl-2) plays a pivotal role in the highly regulated process of apoptosis. We have recently cloned a newly identified member of this family, BCL2L12, which was found to be differentially expressed in many tumors. It is known that topotecan and methotrexate act through induction of apoptosis in cancer cells. In(More)
Apoptosis is a type of programmed cell death involved in many crucial biological processes. It represents the basic mechanism for the action of chemotherapeutic agents, such as doxorubicin and carboplatin. Both are able to cause cell death through the induction of apoptosis in the human leukemic cell line HL-60. We investigated the possible alterations in(More)
We live in a world of rapidly changing advances in technology, particularly artificial intelligence and connectivity. Rather than a general artificial intelligence the reality is that we are moving more towards a world populated with specialist artificial intelligence systems. Therefore we are likely to have specialist medical intelligences, specialist(More)
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