Kosta G. Kostov

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OBJECTIVES It is still debated if pre-existing minority drug-resistant HIV-1 variants (MVs) affect the virological outcomes of first-line NNRTI-containing ART. METHODS This Europe-wide case-control study included ART-naive subjects infected with drug-susceptible HIV-1 as revealed by population sequencing, who achieved virological suppression on first-line(More)
Background.  Although human immunodeficiency virus (HIV)-positive persons on antiretroviral therapy (ART) frequently have chronic liver enzyme elevation (cLEE), the underlying cause is often unclear. Methods.  Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study participants without chronic viral hepatitis were observed to the earliest of cLEE(More)
UNLABELLED Tuberculous spondylitis (TS) frequently poses both diagnostic and therapeutic challenges. The clinical symptoms, radiological imaging studies and laboratory tests are quite often inconclusive in the early stages of the disease. GOAL To identify early clinical symptoms, review results from radiological imaging studies and laboratory tests to(More)
This work reports the development of atmospheric pressure plasma reactor with dielectric barrier discharge DBD for material treatment. The DBD discharge has been generated in planar geometry reactor powered by ac voltage provided by conventional high voltage transformer. The dielectric barrier consisted of two glass slabs, which cover both reactor(More)
This method can be applied to the non-drug treatment of diseases. It provides an exact evaluation of the healing effect by keeping the acupuncture point from overload. This method is realized by a bistable/monostable square wave oscillator. The electrical pulses for the treatment of the acupuncture point are delivered from the noninverted oscillator output.(More)