Korey D Griffin

Learn More
Many G protein-coupled receptors activate growth factor receptors, although the mechanisms controlling this transactivation are unclear. We have identified two proline-rich, SH3 binding sites (PXXP) in the carboxyl-terminal tail of the human P2Y(2) nucleotide receptor that directly associate with the tyrosine kinase Src in protein binding assays.(More)
The P2Y 2 nucleotide receptor (P2Y 2 R) contains the integrin-binding domain arginine-glycineaspartic acid (RGD) in its first extracellular loop, raising the possibility that this G protein–coupled receptor interacts directly with an integrin. Binding of a peptide corresponding to the first extracellular loop of the P2Y 2 R to K562 erythroleukemia cells was(More)
  • 1