Konstantinos Kafchitsas

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Treatment of an underlying disease is often initiated after the occurrence of an osteoporotic fracture. Our aim was to investigate whether teriparatide (PTH 1-34) and strontium ranelate affect fracture healing in ovariectomized (OVX) rats when provided for the first time after the occurrence of an osteoporotic fracture. We combined the model of an OVX rat(More)
BACKGROUND Osteoporosis can cause severe fractures of bone structures. One important indicator for pathology is a lowered bone mineral density (BMD) - conventionally assessed by dual-energy X-ray absorptiometry (DXA). Dual-energy CT (DECT) - being an alternative that is increasingly used in the clinics - allows the computation of the spatial BMD(More)
PURPOSE To evaluate the feasibility of phantomless in vivo dual-energy computed tomography (CT)-based three-dimensional (3D) bone mineral density (BMD) assessment in comparison with dual x-ray absorptiometry (DXA). MATERIALS AND METHODS This retrospective study was approved by the institutional review board, and the requirement to obtain informed consent(More)
The assessment of bone mineral density (BMD) in vertebrae is critical for the diagnosis of osteoporosis. Recent developments in dual-source CT allow for the simultaneous acquisition of two image data sets with different X-ray tube energies – dual-energy CT (DECT). We present a comprehensive approach for assessing the density of the trabecular bone in(More)
BACKGROUND Giant cell tumor of bone near the knee joints is a dilemma for the operating surgeon. Curettage and bone grafting have a high recurrence, whereas wide resection has a reduced recurrence rate with the compromise of limb function. MATERIALS AND METHODS Thirty-eight patients with histologically proven giant cell tumor near the knee joint were(More)
The aim of this study was to evaluate the feasibility of a new method, which should help to avoid cage subsidence after vertebrectomy in short fusions. After implantation of an extendable vertebral body replacement (VBR) the two adjacent endplates to the fractured or destroyed vertebra were augmented with bone cement using the anterior approach in 20(More)
To evaluate quantitative dual-energy computed tomography (DECT) for phantomless analysis of cancellous bone mineral density (BMD) of vertebral pedicles and to assess the correlation with pedicle screw pull-out strength. Twenty-nine thoracic and lumbar vertebrae from cadaver specimens were examined with DECT. Using dedicated post-processing software, a(More)
Interventional procedures are associated with high radiation doses for both patients and surgeons. To reduce the risk from ionizing radiation, it is essential to minimize radiation dose. This prospective study was performed to evaluate the effectiveness in reducing radiation dose during facet joint injection in the lumbar spine and to evaluate the(More)
BACKGROUND Animal bone models are inevitable for musculoskeletal research. The induction of a local bone tumor is complex and time consuming. In this study a new model is presented using a direct implantation of tumor cells into the bone without a preliminary passaging of the cells. METHODS A three-dimensional matrix consisting of alginate spheroids and(More)
The study was carried out to evaluate MRI findings following osteochondral auto-grafting in femoral condyles and talus, and to correlate these with the clinical outcome. Thirty-three patients (20 knees, 13 ankles) were examined 1 to 4 years after operation using MRI, Lysholm Knee Score and Foot and Ankle Osteoarthritis Score. Clinical examination showed(More)