Konstantinos E Vardakis

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BACKGROUND The aim of the present interim analysis was to compare the clinical efficacy and safety of the generic clopidogrel besylate (CB) with the innovator clopidogrel hydrogen sulphate (CHS) salt in patient groups eligible to receive clopidogrel. METHODS A 2-arm, multicenter, open-label, phase 4 clinical trial. Consecutive patients (n=1,864) were(More)
BACKGROUND In the present clinical trial, we compared the efficacy and safety of the generic clopidogrel besylate (CB) with the innovator clopidogrel hydrogen sulfate (CHS) salt in patients eligible to receive clopidogrel. METHODS A prospective 2-arm, multicenter, open-label, phase 4 clinical trial. Consecutive patients (n = 1864) were screened and 1800(More)
OBJECTIVES The aim of the study was to evaluate whether left ventricular (LV) mechanics are better under LV-based pacing than under right ventricular (RV) apical pacing in patients with permanent atrial fibrillation (AF) after atrioventricular junction (AVJ) ablation. BACKGROUND "Ablate and pace" is an acceptable therapy for drug-refractory AF. However,(More)
AIMS To compare the effects of sotalol and metoprolol on heart rate, during isotonic (ITE) and isometric (IME) exercise and daily activities, in digitalized patients with chronic atrial fibrillation. METHODS AND RESULTS The study had a randomized, single-blinded, crossover design. Twenty-three patients with chronic atrial fibrillation received placebo for(More)
OBJECTIVES The purpose of this study was to assess rest and stress atrial coronary blood flow (CBF) velocity and flow reserve. BACKGROUND Because of the limitations of the methods used until now for assessing myocardial perfusion (MP) in the small mass of atrial tissue, data are lacking for human atrial MP. METHODS Seventeen patients with suitable(More)
STUDY OBJECTIVES Asynchronous ventricular activation, as induced by ventricular pacing, is known to affect left ventricular (LV) systolic and diastolic function and myocardial blood flow. However, it is not clear whether the long-term disturbances it causes are reversible after the restoration of the normal ventricular activation sequence. DESIGN In this(More)
man, with a clear medical history was admitted to the outpatients department complaining of a two hour retrosternal pain with accompanying sweating and nausea. The physical examination revealed normal body type, 65 bpm heart rate and 130/75 mmHg arterial pressure. Cardiac tones were discrete, rhythmic, without additional sounds and the lung auscultation was(More)
AIMS To examine whether atrial and ventricular effective refractory periods exhibit circadian variation and whether the latter is correlated with fluctuations in autonomic nervous system tone. METHODS AND RESULTS We studied 24 patients aged 67.1 +/- 9.6 years, 11 of whom were paced for complete heart block and 13 for sick sinus syndrome. Atrial and(More)
BACKGROUND High serum levels of total homocysteine (tHcy) are common in dialysis patients with end-stage renal disease (ESRD). We assumed that these patients may have decreased response to conventional folic acid (FOL) and vitamin B12 (B12) administered orally. This study aimed to evaluate the efficacy of an intravenous (i.v.) B12 regimen in ESRD patients(More)
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