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  • Emmanuelle Graciet, Rong-gui Hu, Konstantin Piatkov, Joon Haeng Rhee, Erich M. Schwarz, Alexander Varshavsky
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2006 (First Publication: 28 February 2006)
  • The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Primary destabilizing N-terminal residues (Nd(p)) are recognized directly by the targetingExpand
  • Zanxian Xia, Ailsa Webster, Fangyong Du, Konstantin Piatkov, Michel Ghislain, Alexander Varshavsky
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 2008 (First Publication: 29 August 2008)
  • Substrates of a ubiquitin-dependent proteolytic system called the N-end rule pathway include proteins with destabilizing N-terminal residues. N-recognins, the pathway's ubiquitin ligases, containExpand
  • Rebecca E. Connor, Konstantin Piatkov, Alexander Varshavsky, David A. Tirrell
  • Chemistry, Medicine
  • Chembiochem : a European journal of chemical…
  • 2008 (First Publication: 15 February 2008)
  • A chromatographic assay was used to identify ten noncanonical amino acids that can be appended to the N terminus of peptides and proteins by the L,F-transferase of Escherichia coli. A model proteinExpand
  • Konstantin Piatkov, Luca Colnaghi, Miklós Békés, Alexander Varshavsky, Tony T Huang
  • Biology, Medicine
  • Molecular cell
  • 2012 (First Publication: 28 December 2012)
  • Deamidation of N-terminal Gln by the Ntaq1 Nt(Q)-amidase is a part of the Arg/N-end rule pathway, a ubiquitin-dependent proteolytic system. Here we identify Gln-Usp1(Ct), the C-terminal fragment ofExpand