Konstantin Kostov

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All chemical and biological reactions involve atomic motion, embodied in dynamic structural changes. Identifying these changes is the goal of time-resolved crystallography. The "raw" output of a time-resolved macromolecular crystallography experiment is the time-dependent set of difference electron density maps that span the desired time range and display(More)
This thesis aims to bring clarity to the dimensioning aspects and limiting factors of the modular multilevel converter (MMC). Special consideration is given to the dc capacitors in the submodules as they are a driving factor for the size and weight of the converter. It is found that if the capacitor voltages are allowed to increase by 10% the stored energy(More)
The initial output of a time-resolved macromolecular crystallography experiment is a time-dependent series of difference electron density maps that displays the time-dependent changes in underlying structure as a reaction progresses. The goal is to interpret such data in terms of a small number of crystallographically refinable, time-independent structures,(More)
A recent theory for the long time dynamics of flexible chain molecules is applied for the first time to a peptide of biological importance, the neurotransmitter met-enkephalin. The dynamics of met-enkephalin is considerably more complicated than that of the previously studied glycine oligomers; met-enkephalin contains the interesting motions of phenyl(More)
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