Konstantin Halachev

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Epigenome mapping consortia are generating resources of tremendous value for studying epigenetic regulation. To maximize their utility and impact, new tools are needed that facilitate interactive analysis of epigenome datasets. Here we describe EpiExplorer, a web tool for exploring genome and epigenome data on a genomic scale. We demonstrate EpiExplorer's(More)
The EpiGRAPH web service http://epigraph.mpi-inf.mpg.de/ enables biologists to uncover hidden associations in vertebrate genome and epigenome datasets. Users can upload sets of genomic regions and EpiGRAPH will test multiple attributes (including DNA sequence, chromatin structure, epigenetic modifications and evolutionary conservation) for enrichment or(More)
The eROSE plugin for ECLIPSE uses version archives to guide programmers: You changed fKeys[] and eROSE suggests you to change initDefaults(), because both items always have been changed together in the past. In addition, eROSE points out item coupling that is undetectable by program analysis, for instance between fKeys[] and a properties file. All eROSE(More)
MOTIVATION Recurrent DNA breakpoints in cancer genomes indicate the presence of critical functional elements for tumor development. Identifying them can help determine new therapeutic targets. High-dimensional DNA microarray experiments like arrayCGH afford the identification of DNA copy number breakpoints with high precision, offering a solid basis for(More)
EpiGRAPH • regression: A toolkit for (epi-)genomic correlation analysis and prediction of quantitative attributes Five years ago, the human genome sequence was published, an important milestone towards understanding human biology. However, basic cell processes cannot be explained by the genome sequence alone. Instead, further layers of control such as the(More)
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