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Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project. We propose a molecular(More)
Close interaction between biosynthetic, proliferative and overall activities of nucleic acids in tumor epithelial cells, on the one hand, and histo-hematic barrier of peritumorous area, on the other, has been investigated. Nucleolar organizer regions in prostate cancer appeared very active and the interaction of histo-hematic barrier components much closer(More)
The status of anatomy-morphology of maxillary mucosa depending on the time of interconnection between the maxillary sinus and oral cavity, the size of it and its function were studied. The study was conducted on 25 patients and 20 cadavers. Changes in the mucous membrane of the maxillary sinus in relation to some of factors are discussed.
Sets of conventional macroscopic and up-to-date histochemical techniques were employed to study hearts from 267 patients who had died of essential hypertension, atherosclerosis or secondary renal hypertension. Excessive cardiac mass was found disease-specific and related to the time since hypertension onset. Cardiac hypertrophy was augmenting with growing(More)
Renal cell carcinoma (RCC) is a tumor that is typical of late metastases detected within 3 years after radical nephrectomy in 85% of cases. RCC most commonly metastasizes to the lung, bone, liver, and brain; the pancreas is involved in no more than 0.25-3% of cases. The paper describes a unique clinical case of multiple late pancreatic metastases from clear(More)
Indices of Ki67, Bc12 expression, mutant gene p53, nucleolar organizers activity and the percentage of cells having nucleic acids levels higher or lower of the diploid levels were determined in prostatic epithelium in cancer, in the peritumorous area and in the area of benign prostatic hyperplasia. A considerable variability of the tumor epithelium by the(More)
A total of 134 samples of intact prostate tissue, nodular hyperplasia and prostate cancer were examined. Number of androgen-positive cells was 28.51 +/- 3.50%, Ki-67 expression index - 2.76 +/- 0,45% and Bcl-2--6.25 +/- 1.38% in nodular hyperplastic tissue. In peritumorous epithelial tissue, that parameter dropped to 20.60 +/- 3, 10%, while stromal E+ cells(More)