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Journals and Conferences
Acetylation of α-tubulin was studied in cultures of human hepatocytes under the influence of selective inhibitors of histone deacetylases HDAC6 and SIRT-2 — tubastatin A and… (More)
A diverse collection of 40 derivatives of benzohydroxamic acid (BHAs) of various structural groups were synthesized and tested against hepatitis C virus (HCV) in full-genome replicon assay. Some of… (More)
Recently we reported benzohydroxamic acids (BHAs) as potent and selective inhibitors of hepatitis C virus (HCV) replicon propagation. In this work 12 pyridine hydroxamic acids (PHAs) were synthesized… (More)
A highly selective inhibitor of histone deacetylase 6, tubastatin A, was synthesized in four steps under smooth and safe reaction conditions.
H epatitis c is one of the most dangerous and widespread viral diseases. currently, the World Health Organization estimates that about 170 million people are infected with the hepatitis c virus… (More)
A four-stage synthesis of highly selective inhibitor of histone deacetylase 6--Tubastatin A was carried out. Convenient and safety reaction conditions were used throughout the synthesis.
Three structural isomers of pyridyl-4-oxy-substituted N-hydroxy amides of cinnamic acid (PyOCHA) have been synthesized for the first time. The relationship between their antiviral activity against… (More)
According to recently published results, cinnamic hydroxamic acid (CHA) inhibits replication of hepatitis C virus (HCV). We synthesized a structural analogue of CHA, i.e.,… (More)