Konstantin-A. Hossmann

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The cellular mechanisms underlying functional hyperemia—the coupling of neuronal activation to cerebral blood vessel responses—are not yet known. Here we show in rat cortical slices that the dilation of arterioles triggered by neuronal activity is dependent on glutamate-mediated [Ca2+]i oscillations in astrocytes. Inhibition of these Ca2+ responses resulted(More)
Mutations in the X-chromosomal L1CAM gene lead to severe neurological deficits. In this study, we analyzed brains of female mice heterozygous for L1 (L1+/−) to gain insights into the brain structure of human females carrying one mutated L1 allele. From postnatal day 7 onward into adulthood, L1+/− female mice show an increased density of neurons in the(More)
The history of science has always been dominated by a small number of individuals who due to the fortunate combination of sharp intelligence and charismatic leadership opened new vistas to unforeseen developments and discoveries. Igor Klatzo was one of these. A descendant of noble Russian and Hanseatic families, he was born 1916 in Saint Petersburg. During(More)
The effect of transient focal cerebral ischemia on protein regulation was studied in mice using multiparametric immunohistochemistry. Injury was characterized by measurements of blood flow, regional protein synthesis and terminal transferase biotinylated-dUTP nick end labeling (TUNEL). The proteins studied were selected from a previously established list of(More)
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