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  • Colin L. Masters, G. Simms, Nicola A. Weinman, Gerd Multhaup, Barbara L. McDonald, Konrad Beyreuther
  • Medicine, Chemistry
  • Proceedings of the National Academy of Sciences…
  • 1985 (First Publication: 1 June 1985)
  • We have purified and characterized the cerebral amyloid protein that forms the plaque core in Alzheimer disease and in aged individuals with Down syndrome. The protein consists of multimericContinue Reading
  • Matias Simons, Patrick D. Keller, Bart De Strooper, Konrad Beyreuther, Carlos G Dotti, Keith Simons
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1998 (First Publication: 26 May 1998)
  • The amyloid precursor protein (APP) plays a crucial role in the pathogenesis of Alzheimer's disease. During intracellular transport APP undergoes a series of proteolytic cleavages that lead to theContinue Reading
  • Andreas Weidemann, Simone Eggert, +6 authors Genevieve Evin
  • Chemistry, Medicine
  • Biochemistry
  • 2002 (First Publication: 1 February 2002)
  • Proteolytic processing of the transmembrane domain of the amyloid precursor protein (APP) is a key component of Alzheimer's disease pathogenesis. Using C-terminally tagged APP derivatives, we haveContinue Reading