Konomu Yokotani

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Somatostatin is known to have inhibitory effects on the release and action of a wide variety of gut peptides. Previous studies in vivo have suggested a potential inhibitory role for somatostatin even on its own secretion. To determine whether this autoregulatory effect is the result of a direct action of the peptide on the cell that is responsible for its(More)
Functional roles of adrenoceptors in parietal cells were pharmacologically investigated using isolated canine parietal cells. In the crude membranes obtained from preparations highly purified in parietal cells (> 95% of purity), the specific binding of [3H]dihydroalprenolol (DHA) was observed with a Kd value of 2.9 nM and Bmax of 234 fmol/mg protein, while(More)
The functional role of the cholinergic nervous system in regulating gastrin release was investigated using enriched canine antral G cells. Gastrin content was 30.1 +/- 2.9 pmol per well and basal gastrin release was 900 +/- 27 fmol per well (n = 45). Carbachol (10(-8) to 10(-5) M) dose-dependently stimulated gastrin release with a maximal stimulatory(More)
We conduct a two-stage game experiment with a non-excludable public good. In the first stage, two subjects choose simultaneously whether or not they commit to contributing nothing to provide a pure public good. In the second stage, knowing the other subject’s commitment decision, subjects who did not commit in the first stage choose contributions to the(More)
† We thank Takenori Inoki, Mamoru Kaneko, Hajime Miyazaki, Toru Mori, Mancur Olson, Mitsuo Suzuki, two anonymous referees, and Economic Science Association conference participants for their helpful comments and discussions. This research was partially supported by the Zengin Foundation for the Studies on Economics and Finance, Grant in Aid for Scientific(More)
We conducted a two-stage game experiment with a non-excludable public good. In the first stage, two subjects choose simultaneously whether or not they commit to contributing nothing to provide a pure public good. In the second stage, knowing the other subject's commitment decision, subjects who selected not to commit in the first stage choose contributions(More)
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