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Analysis of the circular RNA transcriptome in endometrial cancer
The circular transcriptome specific for EC as determined by RNA sequencing found that the overall abundance of circRNAs is lower in EC than in normal endometrium and there are numerous ‘hotspot’ genes from whichcircRNAs are transcribed that may account for alterations in circRNA expression between the normal and malignantendometrium. Expand
Characterization of circular RNAs landscape in multiple system atrophy brain
- B. Chen, J. D. Mills, Konii Takenaka, N. Bliim, G. Halliday, M. Janitz
- Biology, Medicine
- Journal of neurochemistry
- 1 November 2016
Five circRNAs, namely IQCK, MAP4K3, EFCAB11, DTNA, and MCTP1, were identified and validated as specifically over‐expressed in MSA frontal cortex and revealed their over‐expression in the white matter of the MSA cortical tissue. Expand
The emerging role of long non-coding RNAs in endometrial cancer.
- Konii Takenaka, B. Chen, S. Modesitt, F. Byrne, K. Hoehn, M. Janitz
- Biology, Medicine
- Cancer genetics
- 1 October 2016
This review summarizes recent advances in the understanding of lncRNAs in cancer biology and highlights the potential for lncRNA as diagnostic biomarkers and therapeutics, and focuses on the poorly understood role of l NC RNAs in endometrial cancer. Expand
Transcriptome landscape of long intergenic non-coding RNAs in endometrial cancer.
Four lincRNAs, characterised in this study, represent high priority genes to be tested for functional significance in the pathogenesis and/or progression of endometrial cancer and have potential to be released into the bloodstream. Expand
RNA sequencing reveals pronounced changes in the noncoding transcriptome of aging synaptosomes
This study uncovers a new layer of transcriptional regulation which is targeted by aging within the local environment of interconnecting neuronal cells within aging mice. Expand
Analysis of the Circular Transcriptome in the Synaptosomes of Aged Mice
This work presents the first comprehensive survey of the circular transcriptome in mammalian synapses using a mouse model and presents 16 genes that express solely circRNAs, without linear RNAs co-expression, exclusively in young and aged synaptosomes, suggesting a synaptic gene network that functions along canonical splicing activity. Expand