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Efficient bacterial recombinational DNA repair involves rapid cycles of RecA filament assembly and disassembly. The RecX protein plays a crucial inhibitory role in RecA filament formation and stability. As the broken ends of DNA are tethered during homologous search, RecA filaments assembled at the ends are likely subject to force. In this work, we(More)
In the present study, we have carried out extensive GUSAR and conventional 3D QSAR analyses of 49 synthetic prodiginines possessing moderate to high activities against multi drug resistant strain of Plasmodium falciparum. 2D and 3D descriptors, various statistical parameters, viz. R 2, R adj 2 , standard error, Y-randomization, etc., were checked to build(More)
Herein, we have built up structure–activity relationship (SAR), k-nearest neighbor, quantum mechanical, field similarity analysis as well as a sufficient number of quantitative SAR (QSAR) models to explore the pharmacological activity of Xanthones as α-glucosidase inhibitors. To achieve good results, SAR and QSAR have been investigated apropos of a new(More)
Structures of crystals of Mycobacterium tuberculosis RecA, grown and analysed under different conditions, provide insights into hitherto underappreciated details of molecular structure and plasticity. In particular, they yield information on the invariant and variable features of the geometry of the P-loop, whose binding to ATP is central for all the(More)
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