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Caspases Are Activated in a Branched Protease Cascade and Control Distinct Downstream Processes in Fas-induced Apoptosis
- H. Hirata, A. Takahashi, M. Sasada
- Biology, ChemistryThe Journal of experimental medicine
- 16 February 1998
It is demonstrated that caspases are organized in a protease cascade, and that each activated caspase plays a distinct role(s) in the execution of Fas-induced cell death.
Calpain-mediated X-linked Inhibitor of Apoptosis Degradation in Neutrophil Apoptosis and Its Impairment in Chronic Neutrophilic Leukemia*
- Susumu Kobayashi, K. Yamashita, A. Takahashi
- Medicine, BiologyThe Journal of Biological Chemistry
- 13 September 2002
It is found that calpains cleave the X-linked inhibitor of apoptosis (XIAP) in vitro, producing fragments that are unable to inhibit caspase-3 and these fragments were detected in normal neutrophils but were unstable and rapidly degraded.
Affinity labeling displays the stepwise activation of ICE-related proteases by Fas, staurosporine, and CrmA-sensitive caspase-8
Findings provide evidence that caspase-8, a CrmA-sensitive protease, is responsible for initiating the stepwise activation of multiple caspases in Fas-stimulated cells.
The role of endothelial interleukin‐8/NADPH oxidase 1 axis in sepsis
- Takashi Miyoshi, K. Yamashita, T. Arai, Kokichi Yamamoto, K. Mizugishi, T. Uchiyama
- Biology, MedicineImmunology
- 1 November 2010
LPS stimulation of endothelial cells causes activation of the IL‐8–Nox1 axis, enhances the production of ROS, and ultimately contributes to the progression of severe sepsis.
Successful allogeneic bone marrow transplantation for acute myelogenous leukemia after drug-induced cardiomyopathy.
An 18-year-old woman with relapsed acute myelogenous leukemia with cardiomyopathy underwent allogeneic BMT from her HLA-identical brother, and had severe CHF, which was controlled using pimobendan and amrinone.
Preliminary Studies on the Rotatorian Fauna of Korea
- Kokichi Yamamoto
- Environmental Science
- 1 April 1953
THOROUGH LIMNOLOGICAL SURVEYS in Korea have not been carried out up to the present time; only a few brief studies on the plankton, especially on the rotatorian fauna, have been made in several…
The expression of co‐stimulatory molecules and their relation‐ ship to the prognosis of human acute myeloid leukaemia: poor prognosis of B7‐2‐positive leukaemia
- Akinori Maeda, Kokichi Yamamoto, M. Sasada
- Medicine, BiologyBritish journal of haematology
- 1 September 1998
The results indicated that B7‐2 is one of the most crucial factors in the prognosis of adult acute leukaemia and can be expected to have an important role in tumour immunity.
Nitric Oxide Derived from Human Umbilical Vein Endothelial Cells Inhibits Transendothelial Migration of Neutrophils
The findings imply the role of NO constitutively generated by HUVECs in protection against excessive neutrophil extravasation and unnecessary tissue damage under physiological conditions.
Plankton Rotatoria in Japanese Inland Waters
- Kokichi Yamamoto
- Environmental ScienceHydrobiologia
- 1 December 1960
The writer examined more than 1500 plankton samples from more than 200 localities which are distributed in almost all parts of Japan, finding that the wider the distribution area, the larger the occurrence rate of pelagic species.