• Citations Per Year
Learn More
Recent studies indicate that the functional renin-angiotensin system (RAS) exists in the adipose tissue. The adipose tissue RAS is proposed in the pathophysiology of metabolic disorders. In the present study, we examined therapeutic effects of irbesartan, an angiotensin II (Ang II) type 1 receptor (AT1R)-specific blocker, in genetically obese diabetic KKAy(More)
Hypertension is highly prevalent worldwide and is one of the major risk factors for cardiovascular and renal diseases. Pathogenesis of hypertension reportedly involves alterations in a variety of tissues and cells, and vascular smooth muscle cells (VSMCs) have important roles in the physiological control of vessel tone and pathophysiological modulation of(More)
Recently, major clinical guidelines for the treatment of hypertension have been revised in several countries.1–9 In these updated guidelines, five classes of antihypertensive drugs, including Ca2þ channel blockers, angiotensin receptor blockers (ARBs), angiotensin-converting enzyme (ACE) inhibitors, diuretics and b-blockers (including ab-blockers), were(More)
  • 1