Koji Murakami

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Adiponectin (also known as 30-kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects(More)
Adipose tissue expression and circulating concentrations of monocyte chemoattractant protein-1 (MCP-1) correlate positively with adiposity. To ascertain the roles of MCP-1 overexpression in adipose, we generated transgenic mice by utilizing the adipocyte P2 (aP2) promoter (aP2-MCP-1 mice). These mice had higher plasma MCP-1 concentrations and increased(More)
BACKGROUND Previous studies have shown cognitive impairment in breast cancer survivors who were exposed to adjuvant chemotherapy. Neural damage by chemotherapy might have played some part in these findings. The current study explored the regional brain volume difference between breast cancer survivors exposed to adjuvant chemotherapy (C+) and those(More)
The adipocyte-derived hormone adiponectin has been shown to play important roles in the regulation of energy homeostasis and insulin sensitivity. In this study, we analyzed globular domain adiponectin (gAd) transgenic (Tg) mice crossed with leptin-deficient ob/ob or apoE-deficient mice. Interestingly, despite an unexpected similar body weight, gAd Tg ob/ob(More)
In obese patients with type 2 diabetes, insulin delivery to and insulin-dependent glucose uptake by skeletal muscle are delayed and impaired. The mechanisms underlying the delay and impairment are unclear. We demonstrate that impaired insulin signaling in endothelial cells, due to reduced Irs2 expression and insulin-induced eNOS phosphorylation, causes(More)
Many natural language processing tasks, including information extraction, question answering and recognizing textual entailment, require analysis of the polarity, focus of polarity, tense, aspect, mood and source of the event mentions in a text in addition to its predicateargument structure analysis. We refer to modality, polarity and other associated(More)
We investigated the adverse effects of adjuvant chemotherapy on the hippocampus in Japanese breast cancer survivors with (n=44) and without (n=31) adjuvant chemotherapy. There were no significant differences in hippocampal volume (magnetic resonance imaging) or additionally in memory function (Wechsler Memory Scale-Revised) between the two groups.
PURPOSE The usefulness of diffusion-weighted imaging (DWI) in the field of neuroradiology has been established. Despite its high contrast resolution, DWI has the disadvantages of susceptibility artifact and chemical shift artifact. We performed DWI of breast cancer with the sensitivity encoding (SENSE) technique. METHODS The subjects were 60 female(More)
This paper describes efforts of NLP researchers to create a system to aid the relief efforts during the 2011 East Japan Earthquake. Specifically, we created a system to mine information regarding the safety of people in the disaster-stricken area from Twitter, a massive yet highly unorganized information source. We describe the large scale collaborative(More)
This paper proposes a new UGC-oriented language technology application, which we call experience mining. Experience mining aims at automatically collecting instances of personal experiences as well as opinions from an explosive number of user generated contents (UGCs) such as weblog and forum posts and storing them in an experience database with(More)