Koji Mishima

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To study the long-term change in nutrient loads from the Hii River to Lake Shinji, water samples were taken repeatedly over a year in 1983/1984 and again in 2001/2002. Annual total nitrogen (TN) loads, estimated from observations of water quality and river flow, increased from 860 to 920 t with a corresponding increase in NO3–N concentration during the cool(More)
In this paper, the authors consider school bullying using digital communication media (such as cell phones, short messaging, emails, blogs, SNS, and BBS) and create a framework whose goal is to help teachers identify whether school bullying is taking place among students. The framework proposed in this paper models interactions among students as a(More)
BACKGROUND The efficacy of B cell-depleting therapies for rheumatoid arthritis underscores antibody-independent functions of effector B cells such as cognate T-B interactions and production of pro-inflammatory cytokines. Receptor activator of nuclear factor κB ligand (RANKL) is a key cytokine involved in bone destruction and is highly expressed in synovial(More)
In situ phosphorus release rates in three contiguous shallow brackish lakes were calculated by considering the amount of water inflow, changes in salinity and phosphorus stock, and loading from phosphorus inflow based on monthly data. The annual amount of sedimental phosphorus relative to that of phosphorus inflow was different for each of the three water(More)
BACKGROUND Anti-programmed cell death 1 antibody nivolumab is a promising agent for various cancers. Immune-related adverse events are recognized; however, bi-cytopenia with nivolumab has not been reported. CASE PRESENTATION A 73-year-old man was diagnosed with advanced primary malignant melanoma of the esophagus with liver, lung, and lymph node(More)
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