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In this paper, the authors consider school bullying using digital communication media (such as cell phones, short messaging, emails, blogs, SNS, and BBS) and create a framework whose goal is to help teachers identify whether school bullying is taking place among students. The framework proposed in this paper models interactions among students as a(More)
BACKGROUND Anti-programmed cell death 1 antibody nivolumab is a promising agent for various cancers. Immune-related adverse events are recognized; however, bi-cytopenia with nivolumab has not been reported. CASE PRESENTATION A 73-year-old man was diagnosed with advanced primary malignant melanoma of the esophagus with liver, lung, and lymph node(More)
BACKGROUND The efficacy of B cell-depleting therapies for rheumatoid arthritis underscores antibody-independent functions of effector B cells such as cognate T-B interactions and production of pro-inflammatory cytokines. Receptor activator of nuclear factor κB ligand (RANKL) is a key cytokine involved in bone destruction and is highly expressed in synovial(More)
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