Learn More
We have examined the growth capacity of keratinocytes isolated from human scalp hair follicles. Like the keratinocytes of glabrous epidermis, most of the colony-forming cells are classified as holoclones or meroclones when analyzed in a clonal assay. Some of them have extensive growth potential, as they are able to undergo at least 130 doublings. Therefore,(More)
The upper region of the outer root sheath of vibrissal follicles of adult mice contains multipotent stem cells that respond to morphogenetic signals to generate multiple hair follicles, sebaceous glands, and epidermis, i.e., all the lineages of the hairy skin. At the time when hair production ceases and when the lower region of the follicle undergoes major(More)
The bin packing problem has been extensively studied and numerous variants have been considered. The k-item bin packing problem is one of the variants introduced by Krause et al. in Journal of the ACM 22(4). In addition to the formulation of the classical bin packing problem, this problem imposes a cardinality constraint that the number of items packed into(More)
The quantum phase transition between the three dimensional Dirac semimetal and the diffusive metal can be induced by increasing disorder. Taking the system of a disordered Z2 topological insulator as an important example, we compute the single particle density of states by the kernel polynomial method. We focus on three regions: the Dirac semimetal at the(More)
Low-frequency neuromuscular electrical stimulation (NMES) has been used as an endurance exercise model. This study aimed to test whether low-frequency NMES increases the phosphorylation of anabolic signaling molecules and induces skeletal muscle hypertrophy, as seen with high-frequency NMES. Using Sprague-Dawley rats, 1 bout of exercise (with dissection(More)
OBJECTIVE Prostaglandin D(2) (PGD(2)) is one of the prostanoids produced during inflammation. Although PGD(2) is known to decrease endothelial permeability through D prostanoid (DP) receptor stimulation, the detailed mechanism is unknown. METHODS AND RESULTS Treatment with PGD(2) (0.1-3 μmol/L) or the DP receptor agonist, BW245C (0.1-3 μmol/L),(More)
The online buffer management problem formulates the problem of queuing policies of network switches supporting QoS (Quality of Service) guarantee. We focus on multi-queue switches in QoS networks proposed by Azar et al. They introduced so-called "the relaxed model". Also, they showed that if the competitive ratio of the single-queue model is at most(More)
Recently, the problems of evaluating performances of switches and routers has been formulated as online problems, and a great amount of results have been presented. In this paper, we focus on managing outgoing packets (called egress traffic) on QoS (Quality of Service) switches, and analyze the performance of one of the most fundamental scheduling policies(More)
The online buffer management problem formulates the problem of queueing policies of network switches supporting QoS (Quality of Service) guarantee. For this problem, several models are considered. In this paper, we focus on shared memory switches with preemption. We prove that the competitive ratio of the Longest Queue Drop (<i>LQD</i>) policy is(More)
Histamine is a mediator of allergic inflammation released mainly from mast cells. Although histamine strongly increases vascular permeability, its precise mechanism under in vivo situation remains unknown. We here attempted to reveal how histamine induces vascular hyperpermeability focusing on the key regulators of vascular permeability, blood flow and(More)