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Novel adjuvants and antigen-delivery systems with immunomodulatory properties that shift the allergenic Th2 response towards a Th1 or regulatory T cell response are desired for allergen-specific immunotherapy. This study demonstrates that 200-nm sized biodegradable poly(gamma-glutamic acid) (gamma-PGA) nanoparticles (NPs) are activators of human(More)
OBJECTIVES The aim of this study was to investigate the effect of shift working on the risk of developing impaired glucose tolerance (IGT). METHODS This study comprised 6413 male employees (5608 daytime workers, 512 3-shift workers and 293 2-shift workers) whose work schedules remained constant during the follow-up period (mean follow-up period 9.9(More)
OBJECTIVES The authors investigated the effect of shift working on the risk of obesity using data from the Industry-based Shift Workers' Health (IbSH) study, a retrospective cohort study based on a health care database system belonging to a manufacturing corporation in Japan. METHODS The study database contains data on annual health check-ups and work(More)
OBJECTIVES We investigated whether the association between shift work and hypertension is independent of weight gain. METHODS Subjects were 10,173 male employees (9209 daytime workers, 964 three-shift workers; mean follow-up period: 12.7 years). Hypertension was defined as systolic blood pressure 140 mm Hg or more or diastolic blood pressure 90 mm Hg or(More)
OBJECTIVES The risk of prostate cancer among shift workers was examined in the present industry-based retrospective cohort study. METHODS The study was established based on a health-care database from a Japanese manufacturing corporation. Work schedules of 4995 male workers (mean age = 55.5 years) were followed up retrospectively; mean follow-up period =(More)
BACKGROUND The determination of dihydropyrimidine dehydrogenase (DPD) deficiency is important in avoiding severe 5-fluorouracil (FU) toxicity. The dihydrouracil (UH2)-uracil (Ura) ratio (UH2/Ura) in plasma might be an important indicator of the risk of 5-FU catabolic deficiency. In order to clarify this possibility, the pyrimidine metabolites and the(More)
BACKGROUND Thymidine phosphorylase (TP) is a key enzyme involved in pyrimidine nucleoside metabolism. Dihydropyrimidine dehydrogenase (DPD) is the major catabolic enzyme of 5-fluorouracil (5-FU). These are important enzymes in the pyrimidine salvage pathway and are considered to be key enzymes for determining the prognosis of patients with gastrointestinal(More)
Pancreatic cancer contains both fibrotic tissue and tumor cells with embedded vasculature. Therefore anti-cancer nanoparticles need to extravasate from tumor vasculature and permeate thick fibrotic tissue to target tumor cells. To date, permeation of drugs has been investigated in vitro using monolayer models. Since three-dimensional migration of(More)
OBJECTIVES We examined the contextual effect of workplace social capital on systolic blood pressure (SBP). DESIGN Cross-sectional. SETTING A conglomerate from 58 workplaces in Japan. PARTICIPANTS Of the 5844 workers at a Japanese conglomerate from 58 workplaces, 5368 were recruited. Individuals who received drugs for hypertension (n=531) and who(More)