Koji Hasegawa

Hiromichi Wada9
Koh Ono7
Takahiro Horie6
Noriko Satoh-Asahara6
Akira Shimatsu4
9Hiromichi Wada
7Koh Ono
6Takahiro Horie
6Noriko Satoh-Asahara
4Akira Shimatsu
Learn More
AIMS A significant increase in congestive heart failure (CHF) was reported when the anti-ErbB2 antibody trastuzumab was used in combination with the chemotherapy drug doxorubicin (Dox). The aim of the present study was to investigate the role(s) of miRNAs in acute Dox-induced cardiotoxicity. METHODS AND RESULTS Neuregulin-1-ErbB signalling is essential(More)
BACKGROUND Cholesterol efflux from cells to apolipoprotein A-I (apoA-I) acceptors via the ATP-binding cassette transporters ABCA1 and ABCG1 is thought to be central in the antiatherogenic mechanism. MicroRNA (miR)-33 is known to target ABCA1 and ABCG1 in vivo. METHODS AND RESULTS We assessed the impact of the genetic loss of miR-33 in a mouse model of(More)
Intracellular calcium is one of the important signals that initiates the myogenic program. The calcium-activated phosphatase calcineurin is necessary for the nuclear import of the nuclear factor of activated T cell (NFAT) family members, which interact with zinc finger GATA transcription factors. Whereas GATA-6 plays a role in the maintenance of the(More)
MicroRNAs (miRs) are small non-protein-coding RNAs that bind to specific mRNAs and inhibit translation or promote mRNA degradation. Recent reports have indicated that miR-33, which is located within the intron of sterol regulatory element-binding protein (SREBP) 2, controls cholesterol homoeostasis and may be a potential therapeutic target for the treatment(More)
  • Hiromichi Wada, Shuichi Ura, Shuji Kitaoka, Noriko Satoh-Asahara, Takahiro Horie, Koh Ono +10 others
  • 2011
The mechanisms that lead from obesity to atherosclerotic disease are not fully understood. Obesity involves angiogenesis in which vascular endothelial growth factor-A (VEGF-A) plays a key role. On the other hand, vascular endothelial growth factor-C (VEGF-C) plays a pivotal role in lymphangiogenesis. Circulating levels of VEGF-A and VEGF-C are elevated in(More)
  • Maki Komiyama, Hiromichi Wada, Shuichi Ura, Hajime Yamakage, Noriko Satoh-Asahara, Akira Shimatsu +4 others
  • 2013
Cigarette smokers are generally known to gain weight after quitting smoking, and such weight gain is thought to contribute to the worsening of glucose tolerance. While smoking cessation therapy such as nicotine replacement is useful to minimize post-cessation weight gain, substantial gain occurs even during the therapy. The purpose of the present study was(More)
The changes in length on the two opposite sides of etiolated radish (Raphanus sativus) hypocotyls prior to, and following gravitropic stimulation, were measured using an infrared-imaging system. It was observed that the growth suppression on the upper side began first at least 10 min after the onset of gravitropic stimulation, and after 30 min the(More)
  • Noriko Satoh-Asahara, Akira Shimatsu, Yousuke Sasaki, Hidenori Nakaoka, Akihiro Himeno, Mayu Tochiya +7 others
  • 2012
OBJECTIVE It has recently been highlighted that proinflammatory (M1) macrophages predominate over anti-inflammatory (M2) macrophages in obesity, thereby contributing to obesity-induced adipose inflammation and insulin resistance. A recent clinical trial revealed that highly purified eicosapentaenoic acid (EPA) reduces the incidence of major coronary events.(More)
Noise signals generated by rotating machines such as diesel engines, cutting machines, fans, etc. may be mod-eled as noisy sinusoidal signals which can be successfully suppressed by narrowband active noise control (ANC) systems. In this paper, the statistical performance of such a conventional filtered-X LMS (FXLMS) based nar-rowband ANC system is(More)