Koichiro Uekusa

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BACKGROUND The four-vessel occlusion method introduced by Pulsinelli et al. is widely used as an experimental model for reversible forebrain ischemia in rats. METHOD In this study, we further developed highly reproducible model of reversible forebrain ischemia. Under the microscope the visible vertebral arteries at the second vertebra could be easily(More)
Flumazenil was studied on cocaine intoxicated rats for its preventive effect on seizure, death and loss of righting reflex. Two minutes after the intraperitoneal injection of cocaine (70 mg/kg) into a rat, flumazenil and diazepam were administered at the clinically corresponding dose intraperitoneally. Flumazenil at a dose 0.125 mg/kg extended the onset(More)
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