Koichiro Nishimura

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The 5-bromo-2-methylamino-8-methoxyquinazoline (1) is a key intermediate in our drug discoveries. Compound 1 bears a monomethylamino group at the 2-position of the quinazoline ring. This compound has been synthesized from 6-bromo-2-fluoro-3-methoxybenzaldehyde by a synthetic route including a total of four isolation processes in the medicinal chemistry(More)
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