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A series of 1-oxo-2-(3-piperidyl)-1,2,3,4-tetrahydroisoquinolines and related analogues were prepared and evaluated for their bradycardic activities in isolated right atrium and in anesthetized rats. (+/-)-6,7-Dimethoxy-2-[1-[3-(3,4-methylenedioxyphenoxy)propyl]-3-piperidyl]-1,2,3,4-tetrahydroisoquinoline (4) was chosen as a lead, and structural(More)
Snapdragon seedlings, 20 mm in length, were cut into 5 segments from the cotyledon to the root, which were cultured in vitro on hormone-free MS medium. Adventitious shoot formation was highest in the basal hypocotyl segments with stimulation by the addition of BA. Endogenous cytokinins were higher in the basal hypocotyl segments than in the two upper(More)
Microorganisms from culture collections and isolates from nature were screened for the ability to catalyze the regioselective glucosylation of pyridoxine (PN) to produce pyridoxine 5'-alpha-D-glucoside (PN-5'-alpha-G) or pyridoxine 4'-alpha-D-glucoside (PN-4'-alpha-G). Transglucosylation activity specific to 5'-position of PN was found in fungi belonging to(More)
In the context of designing a scalable overlay network to support decentralized topic-based pub/sub communication, the Minimum Topic-Connected Overlay problem (Min-TCO in short) has been investigated: Given a set of t topics and a collection of n users together with the lists of topics they are interested in, the aim is to connect these users to a network(More)
The poor oral bioavailability arising from poor aqueous solubility should make drug research and development more difficult. Various approaches have been developed with a focus on enhancement of the solubility, dissolution rate, and oral bioavailability of poorly water-soluble drugs. To complete development works within a limited amount of time, the(More)