Koichi Nakadate

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Treatment with serotonin and acetylcholine depletors reduced the number of synapses in the rat hippocampus. Animals that received the drug treatment lost a substantial number of synapses and showed an apparent impairment in memory acquisition. Although the animals were behaviorally impaired following the treatment, spatial memory was nonetheless eventually(More)
Incidence of “limy bile” is relatively rare and only 120 cases have been recorded in Japan so far. The present report is to add five more cases operated on at our clinic. On chemical analysis by atomic absorption spectrophotometry calcium carbonate was the major constituent of solid portion and ranged from 73.5 to 88.5%. On crystallographic analyses, the(More)
Biogenic amines have a trophic-like role for the formation and the maintenance of synapses in the CNS. We examined the changes in the number of synaptic profiles in the developing and adult rat visual cortex following selective depletion of noradrenaline and/or serotonin. By the drug-induced decreases in levels of noradrenaline or serotonin between 1 and 2(More)
Chemical analyses by atomic absorption spectrophotometry and crystallographic studies by the X-ray powder diffraction method and infrared spectrometry (KBr-disk method) were made on 33 cases of calcium carbonate gallstone or so-called limy bile. Chemically, calcium carbonate was the major constituent, ranged from 33.7 to 91.6% and averaged 77.8%.(More)
Both serotonin and noradrenaline affect synapse formation and maintenance in the CNS. Although we previously demonstrated that serotonin regulates synaptic density via activation of serotonin(2A) receptor, it was still unclear which receptor subtype mediates the function of noradrenaline. In the present study we tried to identify the noradrenaline receptor(More)
The concentrations of metal elements in gallstones were measured by absorption spectrometry. Crystallographic analysis by the powder X-ray diffraction method was also performed. For all stones calcium was the major component. In calcium carbonate stones aragonite form, one of the CaCO3 polymorphs and usually unstable in nature, was dominant. As a whole,(More)
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