Koichi Ishii

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OBJECTIVE Most patients with schizophrenia first start with a single antipsychotic, and yet most finally end up 'switching' or using 'polypharmacy'. The objective of this study was to examine the evolution of antipsychotic switch and polypharmacy in the real-world from a longitudinal perspective. METHODS A systematic review of longitudinal antipsychotic(More)
Experiments were done on the tortoise, Testudo hermanni (anesthetized), or on its lung-vagus preparation in which all other internal organs had been removed. By recording the afferent impulse patterns in fine strands of the vagus, three kinds of CO2-sensitive receptors were demonstrated. Heymans-type chemoreceptors: Afferents originating from thoracic(More)
We previously demonstrated that safflower seed extract (SSE) and its major antioxidant constituents, serotonin hydroxycinnamic acid amides, suppressed LDL oxidation in vitro, decreased plasma autoantibody titres to oxidized LDL and attenuated atherosclerotic lesion formation in apoE-deficient mice. In this report, we examined whether SSE, rich in serotonin(More)
Electrophysiological and anatomical experiments were performed to determine the baro- and chemoreceptive area of the turtle, Geoclemmys reevesii. The baro- and chemoreceptive sites are located in the aortic and pulmonary arches and the truncal region. The aortic arch is innervated by both the superior truncal nerve (aortic nerve) and a branch of the(More)
The ethyl acetate (EtOAc)-soluble fraction of a methanol extract of Angelica keiskei roots exhibited cytotoxic activity against 4 human tumor cell lines, HL60 (leukemia), CRL1579 (melanoma), A549 (lung), and AZ521 (stomach). Nine chalcones (1-9), 5 coumarins (10-14), and 4 flavanones (15-18), isolated from the EtOAc-soluble fraction, were examined for their(More)
beta-Phenylethylamine (PEA) is a naturally occurring compound and its structure is close to amphetamine. The effects of PEA on locomotor activity and brain catecholamine metabolism in mice were investigated. Mice were injected with PEA 50 mg/kg intraperitoneally. PEA produced increased locomotor activity between 3 and 6 min, then a decline to 20 min after(More)
Oxygen-sensitive activity was recorded from the branchial nerve of the crayfish Astacus leptodactylus in vitro. After the podobranchial and arthrobranchial nerves branch off to the gill, the branchial nerve terminates in the branchio-cardiac vein wall and its surroundings. When the former 2 branches were cut, irregular spontaneous activity could be recorded(More)
The anatomical structure of oxygen-sensitive receptors in branchio-cardiac veins of a crayfish (Astacus leptodactylus) was studied with fluorescence and electron microscopy. Fluorescent cells were observed in the wall of a restricted part of the branchio-cardiac veins which was electrophysiologically shown to be a chemoreceptor region. Electron microscopy(More)