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BACKGROUND To investigate the hypothesis that MRI derived diffusion-weighted imaging (DWI) and perfusion (MRP) parameters are sensitive image biomarkers for monitoring early antiangiogenic effects and predicting progression free survival (PFS) in advanced hepatocellular carcinoma (HCC). METHODS In this phase II clinical trial, 23 of 34 patients were(More)
PURPOSE To evaluate the diagnostic value of computed tomography perfusion (CTP) in the distinction of hepatocellular carcinomas (HCCs) from metastatic liver tumors. MATERIALS AND METHODS CTP data from 90 liver tumors (HCC 38, metastasis 52) in 31 patients (16 men and 15 women; mean age 60.3 years) were studied. CTP was performed on a 16/64(More)
Morphologic methods such as the Response Evaluation Criteria in Solid Tumors (RECIST) are considered as the gold standard for response assessment in the management of cancer. However, with the increasing clinical use of antineoplastic cytostatic agents and locoregional interventional therapies in hepatocellular carcinoma (HCC), conventional morphologic(More)
BACKGROUND To find prognostic biomarkers in pretreatment dynamic contrast-enhanced MRI (DCE-MRI) water-exchange-modified (WX) kinetic parameters for advanced hepatocellular carcinoma (HCC) treated with antiangiogenic monotherapy. METHODS Twenty patients with advanced HCC underwent DCE-MRI and were subsequently treated with sunitinib. Pretreatment DCE-MRI(More)
The modeling of tracer kinetics with use of low-temporal-resolution data is of central importance for patient dose reduction in dynamic contrast-enhanced CT (DCE-CT) study. Tracer kinetic models of the liver vary according to the physiologic assumptions imposed on the model, and they can substantially differ in the ways how the input for blood supply and(More)
Parametric-fitting approaches for tracer kinetic modeling depend on the capability of a computational method to describe underlying physiologic processes that cause temporal intensity changes in dynamic contrast-enhanced (DCE) images. Rapid scan techniques allow perfusion CT imaging with high temporal resolution. In clinical practice, however, the perfusion(More)
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