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Noisy signal amplification in ultrasensitive signal transduction.
Because intracellular processes are inherently noisy, stochastic reactions process noisy signals in cellular signal transduction. One essential feature of biological signal transduction systems isExpand
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Muscle metabolism during exercise using phosphorus-31 nuclear magnetic resonance spectroscopy in adolescents
Very little has been reported on muscle energetics during exercise in adolescents. This is attributable to the difficulty of subjecting children to muscle biopsy. The purpose of this study was toExpand
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Control of the rate of phosphocreatine resynthesis after exercise in trained and untrained human quadriceps muscles
We examined the effect of differences in exercise intensity on the time constant (tc) of phosphocreatine (PCr) resynthesis after exercise and the relationships betweentc and maximal oxygen uptakeExpand
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Cross talking of network motifs in gene regulation that generates temporal pulses and spatial stripes
Gene regulatory networks contain several substructures called network motifs, which frequently exist throughout the networks. One of such motifs found in Escherichia coli, Saccharomyces cerevisiae,Expand
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Pharmacological profiles of R-96544, the active form of a novel 5-HT2A receptor antagonist R-102444.
We examined the pharmacology of (2R,4R)-4-hydroxy-2-[2-[2-[2-(3-methoxy)phenyl]ethyl]phenoxy]ethyl-1-methylpyrrolidine hydrochloride (R-96544), the active form of a novel 5-HT(2A) receptorExpand
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A Design Principle of Group-level Decision Making in Cell Populations
TLDR
We show that group-level changes in cellular states occur in either a graded or an all-or-none fashion. Expand
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A novel synthesis of 2-deoxy-α-glycosides
Abstract The key step of the synthesis involves the reaction of glycals [3,4,6-tri-O-acetyl- d -glucal (1), the new glycal derivative 4-O-acetyl-1,5-anhydro-2,6-dideoxy-3-C-methyl-3-O-methyl- lExpand
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A Dynamical Phyllotaxis Model to Determine Floral Organ Number
TLDR
We propose a development-based model of floral organ-number determination, improving upon earlier models of plant phyllotaxis that assumed two developmental processes: sequential initiation of primordia in the least crowded space around the meristem and the constant growth of the tip of the stem. Expand
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Plant-inspired pipettes
TLDR
The female sex organ of the liverwort (Marchantia polymorpha) has a characteristic parasol-like form highly suitable for collecting water droplets containing sperm for fertilization. Expand
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Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens.
Although earlier pleuromutilin analogues showed potent in vitro antibacterial activity against some Gram-positive pathogens, their in vivo efficacy was low because of insufficient pharmacokineticExpand
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