Kohtaro Matsui

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This study characterized the phospholipase A(2) (PLA(2)) activity in cerebral cortex of fetal rat brain and investigated effects of chemical inhibition of Ca(2+)-independent PLA(2) (iPLA(2)) on neurite outgrowth and cell development of cortical neurons in vitro. The PLA(2) activity in fetal brain was insensitive to a Ca(2+)-chelator EGTA and was(More)
The alar plate of the prosencephalon differentiates into a tectum-like structure when transplanted into the mesencephalon around the 10-somite stage. Here, we report on the projection pattern of the retinal ganglion cells to the transplants. Optic nerve fibers were labeled with horseradish peroxidase (HRP) and 3H-proline, and the innervation of the optic(More)
The present communication deals with morphological effects of E-64, a thiol protease inhibitor, on primary cultures dissociated from 15-day-old fetal rat brain. Brain cells were treated with different concentrations of E-64 varying from 0.1 to 50 micrograms/ml medium. Numerous cytoplasmic accumulations appeared in neuronal cells, astrocytes and(More)
Neuronal cell culture system has been used for the study of pathochemical evaluations in human degenerative brain disorders, particularly for Krabbe's disease and neuronal ceroid lipofuscinosis. To understand the pathochemistry of Krabbe's disease, we added psychosine into neuronal cell cultures and psychosine treated cells showed the destruction of(More)
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