Kohji Matsuhisa

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Tight junctions (TJs) maintain cellular polarity between the apical and basolateral region of epithelial cells. Claudin, a tetra-transmembrane protein, plays a pivotal role in the barrier function of TJs. We previously found that a claudin modulator, the C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE), may be a promising candidate for(More)
This article has not been copyedited and formatted. The final version may differ from this version. Abstract Tumor metastasis of epithelium-derived tumors is the major cause of death from malignant tumors. Overexpression of claudin is frequently observed in malignant tumors. However, claudin-targeting anti-metastasis therapy has never been investigated. We(More)
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