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  • Shigenori Ohkawa, Kohji Fukatsu, +5 authors Tadashi Aono
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 1997 (First Publication: 1 February 1997)
  • A series of 2,3-dihydro-5-benzofuranamines (5-aminocoumarans) were developed for the treatment of traumatic and ischemic central nervous system (CNS) injury. Compounds within this class wereContinue Reading
  • Makoto Kamata, Tohru Yamashita, +7 authors Kohji Fukatsu
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2012 (First Publication: 1 June 2012)
  • Spiro-lactone (S)-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor and was found to be metabolically liable in human hepatic microsomes. To remove one of the risk factors in human study byContinue Reading
  • Tohru Yamashita, Makoto Kamata, +14 authors Kohji Fukatsu
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2011 (First Publication: 1 November 2011)
  • The co-crystal structure of the human acetyl-coenzyme A 2 (ACC2) carboxyl transferase domain and the reported compound CP-640186 (1b) suggested that two carbonyl groups are essential for potent ACC2Continue Reading