Kohei Shiota

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PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance.

Naoyuki Kubota, Yasuo Terauchi, +22 authors Tatsuhiko Kadowaki
Molecular cell
1999

Agonist-induced activation of peroxisome proliferator-activated receptor gamma (PPAR gamma) is known to cause adipocyte differentiation and insulin sensitivity. The biological role of PPAR gamma was… (More)

Dynamic expression and essential functions of Hes7 in somite segmentation.

Yasumasa Bessho, Ryuzo Sakata, Setsuko Komatsu, Kohei Shiota, Shuhei Yamada, Ryoichiro Kageyama
Genes & development
2001

The basic helix-loop-helix (bHLH) gene Hes7, a putative Notch effector, encodes a transcriptional repressor. Here, we found that Hes7 expression oscillates in 2-h cycles in the presomitic mesoderm… (More)

Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

Yoshihiko Uehara, Osamu Minowa, +4 authors Naomi Kitamura
Nature
1995

HEPATOCYTE growth factor/scatter factor (HGF/SF) functions as a mitogen, motogen and morphogen for a variety of cultured cells1–7. The genes for HGF/SF and its receptor (the c-met protooncogene… (More)

Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.

Makiko Ishibashi, Sharyn L Ang, Kohei Shiota, Shigetada Nakanishi, Ryoichiro Kageyama, François Guillemot
Genes & development
1995

Mammalian hairy and Enhancer of split homolog-1 (HES-1) encodes a helix-loop-helix (HLH) factor that is thought to act as a negative regulator of neurogenesis. To directly investigate the functions… (More)

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.

Kohichi Yoshida, Tetsuya Taga, +15 authors Tadamitsu Kishimoto
Proceedings of the National Academy of Sciences…
1996

gp130 is a ubiquitously expressed signal-transducing receptor component shared by interleukin 6, interleukin 11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and… (More)

Requirement of Sox2-mediated signaling for differentiation of early Xenopus neuroectoderm.

Masashi Kishi, K Mizuseki, +4 authors Yoshiki Sasai
Development
2000

From early stages of development, Sox2-class transcription factors (Sox1, Sox2 and Sox3) are expressed in neural tissues and sensory epithelia. In this report, we show that Sox2 function is required… (More)

Hedgehog signaling is involved in development of the neocortex.

Munekazu Komada, Hirotomo Saitsu, Masato Kinboshi, Takashi Miura, Kohei Shiota, Makoto Ishibashi
Development
2008

Sonic hedgehog (Shh) function is essential for patterning and cell fate specification, particularly in ventral regions of the central nervous system. It is also a crucial mitogen for cerebellar… (More)

SoxD an Essential Mediator of Induction of Anterior Neural Tissues in Xenopus Embryos

Kenji Mizuseki, Masashi Kishi, Kohei Shiota, Shigetada Nakanishi, Yoshiki Sasai
Neuron
1998

Vertebrate neurogenesis is initiated by the organizer factors that inhibit antineuralizing activities of bone morphogenetic proteins (BMPs) in the ectoderm. Here, we report a candidate mediator of… (More)

Disruption of the mouse RBP-J kappa gene results in early embryonic death.

Chio Oka, Toru Nakano, +8 authors T. Honjo
Development
1995

The RBP-J kappa protein is a transcription factor that recognizes the sequence C(T)GTGGGGA. The RBP-J kappa gene is highly conserved in a wide variety of species and the Drosophila homologue has been… (More)

Holoprosencephaly in human embryos: epidemiologic studies of 150 cases.

Ei Matsunaga, Kohei Shiota
Teratology
1977

One hundred fifty embryos with holoprosencephaly were found among the total of 36,380 conceptuses obtained through induced abortion in the period from 1962 to 1974, giving an overall incidence of 0.4… (More)

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