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Klebsiella pneumoniae carbapenemases (KPCs) have recently been described in Chicago, IL, especially among residents of long-term acute care hospitals (LTACHs). These patients are frequently transferred to local Chicago hospitals for higher acuity of medical care, and rapid detection and isolation of KPC-colonized LTACH residents may interrupt the(More)
To identify proteins interacting in the insulin-signaling pathway that might define new pathways or regulate existing ones, we have employed the yeast two-hybrid system. In a two-hybrid screen of a human liver cDNA library, we identified the human growth factor receptor bound 14 (hGrb14) adaptor protein as a partner of the activated insulin receptor.(More)
As the central bridge connecting nutrient sensing and cellular activities, mTORC1 has for years drawnmuch attention in the cell metabolism field. Its frequent dysregulation in cancer and the diverse therapeutic potential of the mTOR inhibitor rapamycin have further spread its acclaim among cancer biologists, clinicians, and pharmaceutical companies.(More)
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