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In May 2006 the first serious German perfluorinated compounds (PFC) case of contamination became evident. Industrial waste with high concentrations of PFC was manufactured into a soil improver by a recycling company and spread by farmers on agricultural land of the rural area Sauerland, and led to substantial environmental pollution. In parts of the(More)
Residents in Arnsberg, Germany, had been supplied by drinking water contaminated with perfluorooctanoate (PFOA). Biomonitoring data from 2006 evidenced that plasma PFOA concentrations of residents from Arnsberg were 4.5-8.3 times higher than those in reference groups. The introduction of charcoal filtration in July 2006 distinctly reduced PFOA(More)
BACKGROUND Living close to major roads or highways has been suggested to almost double the risk of dying from cardiopulmonary causes. We assessed whether long-term exposure to air pollution originating from motorized traffic and industrial sources is associated with total and cause-specific mortality in a cohort of women living in North Rhine-Westphalia,(More)
We assessed whether long-term exposure to air pollution is associated with all-cause and cause-specific mortality during a period of declining particulate matter concentrations. Approximately 4800 women aged 55 years from North Rhine-Westphalia, Germany, were followed for up to 18 years. Exposure to air pollution was assessed in two ways: (1) using the(More)
Prenatal exposure to polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) can affect neurobehavioral development of infants and children. This effect may be mediated through disruption of thyroid hormone homeostasis. However, epidemiological studies reveal no consistent influence of PCDD/Fs and PCBs on thyroid(More)
OBJECTIVE 40,000 residents in Arnsberg, Germany, had been exposed to drinking water contaminated with perfluorinated compounds (PFCs). Internal exposure of the residents of Arnsberg to six PFCs was assessed in comparison with reference areas. DESIGN AND PARTICIPANTS One hundred seventy children (5-6 years of age), 317 mothers (23-49 years), and 204 men(More)
In May 2006, a serious environmental contamination with perfluorinated compounds (PFCs) became evident in a rural area of North Rhine-Westphalia (NRW) (Region Sauerland), Germany. In autumn 2006, we performed a human biomonitoring study in which a 4-8-fold increase in perfluorooctanoate (PFOA)-plasma concentrations of children, their mothers and men living(More)
BACKGROUND Growing evidence indicates that environmental exposures are more prevalent among socially disadvantaged groups. We investigated the distribution of environmental exposures and health outcomes in preschool children, and examined the role of social position on their associations. METHODS We analysed data from a cross-sectional study on 968(More)
In Arnsberg, Sauerland area Germany, 40000 residents were exposed to PFOA-contaminated drinking water (500-640ng PFOA/l; May 2006). In July 2006, the PFOA-concentrations in drinking water were lowered significantly by activated charcoal filtering in the waterworks, mostly below the limit of detection (10ng/l). A first human biomonitoring study performed in(More)
Perfluorinated compounds (PFCs) were measured in fish samples and blood plasma of anglers in a cross-sectional study at Lake Möhne, Sauerland area, Germany. Human plasma and drinking water samples were analyzed by solid phase extraction, high-performance liquid chromatography (HPLC), and tandem mass spectrometry (MS/MS). PFCs in fish fillet were measured(More)
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