Knut Larsson

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Treatment with serotonin reuptake inhibitors (SRIs) has been shown to cause reduced libido and anorgasmia in women. A large body of evidence suggests that serotonin may influence sexual behavior in estradiol + progesterone primed, gonadectomized female rats; however, the influence of selective SRIs on the estrous behavior of intact female rats has not been(More)
The aminotetralin 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), pharmacologically characterized as a 5-HT1A receptor agonist, produces a pronounced decrease in ejaculation latency in the male rat. Stimulation of 5-HT receptors by a pharmacologically induced increase in the synaptic availability of 5-HT has been shown to produce the opposite effect.(More)
Proinflammatory cytokines have been identified in herniated intervertebral discs in humans, and such cytokines have experimentally been demonstrated to be important in the pathophysiological mechanisms of disc herniation. Cerebrospinal fluid (CSF) and serum concentrations of interleukin (IL)-1β, IL-6, IL-8, interferon (IFN)-γ and tumour necrosis factor(More)
The administration of the 5-hydroxytryptamine (5-HT) precursor 5hydroxytryptophan (5-HTP) (25mg/kg IP), in combination with an inhibitor of peripheral 5-HTP decarboxylase, produced a dose-dependent increase in the ejaculation latency of male rats, and this effect was enhanced by additional treatment with the 5-HT1 receptor antagonist (−)-pindolol (2mg/kg(More)
Oxotremorine (0.1–0.8 mg/kg IP), but not arecoline (12–48 mg/kg IP), or pilocarpine (5–20 mg/kg IP), reduced both the number of intromissions to ejaculation and the ejaculation latency in methscopolamine-pretreated male rats. The effects of oxotremorine, (0.4 mg/kg IP) were completely antagonized by the administration of scopolamine (0.4 mg/kg IP).(More)
Thioridazine (3 mg/kg) and chlorimipramine (1.5–6.0 mg/kg) prolonged the ejaculation latency and increased the number of mounts but did not change the number of intromissions preceding ejaculation. Blockade of peripheral and central noradrenaline receptors by phentolamine and phenoxybenzamine respectively resulted in a suppression of all aspects of the(More)
The methyl-ester-hydrochloride of p-chlorophenylalanine alone (50 or 150 mg/kg i.p.) and in combination (4×100 mg/kg i.p.) with pargyline (100 mg/kg i.p.) caused a shortening of the ejaculation latencies in male rats and an increase in the number of intromissions per minute. No changes were observed in other components of the sexual behavior including(More)
The 5-hydroxytryptamine (5-HT) reuptake inhibitors zimelidine (10 mg/kg IP 1.5 h pretest) or alaproclate (20 mg/kg IP 1.5 h pretest) produced a prolongation of the ejaculation latency and of the post-ejaculatory interval in male rats treated with a subthreshold dose of 5-hydroxytryptophan (5-HTP) (12.5 mg/kg IP 1 h pretest). The 5-HTP-induced (50 mg/kg IP 1(More)
8-OH-DPAT (0.25 mg/kg s.c.) produced a facilitation of the male rat sexual behavior, characterized by a decrease in the number of intromissions preceding ejaculation and in the time to ejaculation. This facilitation of the sexual behavior was antagonized by administration of the 5-HT and β-adrenoceptor antagonist pindolol (4mg/kg i.p.), but not by the(More)
Weanling rats were treated with diazepam, apomorphine, and haloperidol to study the influence of the dopamine (DA) system on the audiogenic immobility reaction and open field locomotory behavior. Treatment with diazepam (0.025, 0.05, and 0.1 mg/kg) caused a dose-dependent shortening of the duration of the immobility response. Treatment with apomorphine(More)