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OBJECTIVE To study the safety and efficacy of the cholinesterase inhibitor donepezil in patients with Parkinson's disease (PD) and cognitive impairment. METHODS This was a double blind, randomised and placebo controlled, crossover study in which 14 patients with PD and cognitive impairment received donepezil (5 or 10 mg per day) or matching placebo during(More)
OBJECTIVE To characterize the psychosocial burden on spouses living with the elderly suffering from mild dementia, stroke and Parkinson's disease, and to identify patient characteristics associated with it. Materials and methods Data on patient-spouse couples came from three studies of patients with stroke (36 couples), mild dementia (92 couples) and(More)
BACKGROUND Hallucinations and delusions are frequent in patients with Parkinson disease (PD) and may have severe clinical consequences for those patients and their caregivers. However, the prevalence and clinical features of these symptoms have not been studied in a representative sample. OBJECTIVE To study the prevalence and clinical correlates of(More)
OBJECTIVE To evaluate whether depression in Parkinson disease (PD) is more closely related to the underlying neuropathological process or to environmental and psychological factors by correlating depression in PD with various clinical and demographic variables. DESIGN Major depression, level of depressive symptoms as measured with the Montgomery-Aasberg(More)
OBJECTIVE To examine the prevalence of anxiety symptoms in hospitalized geriatric patients. DESIGN Controlled cross-sectional study. SUBJECTS Ninety-eight geriatric in-patients and 68 healthy home-dwelling controls of similar age recruited from senior citizen centres. OUTCOME MEASURE Anxiety measured as a current emotional state by Spielberger's(More)
Seasonal fluctuations in mortality are associated with age, outdoor temperature, and influenza. The relative excess winter mortality is approximately twice as high in the UK compared with the Scandinavian countries. Using data from Norway and England plus Wales, this study compares the effect of age, temperature and influenza on winter excess mortality in(More)
BACKGROUND Atrophy of the medial part of the temporal lobe is seen in Alzheimer's disease (AD). We studied the usefulness of CT scan measurements of the medial temporal lobe (MTL) in elderly with suspected dementia. METHODS MTL measurements were done with callipers by three raters, blinded to the diagnosis and to each other, on scans from 110 subjects(More)
BACKGROUND A conspicuously high score on the state part of the State-Trait Anxiety Inventory (STAI) has been observed among geriatric inpatients who are neither demented nor critically ill; 43% of them had a sumscore that, according to Spielberger's criteria, would reflect clinically relevant anxiety symptoms. OBJECTIVES To explore the reasons for this(More)
High frequencies of loss of heterozygosity (LOH) in chromosome 11q22-qter have been observed in various malignancies, including breast cancer. Previous studies on breast carcinomas by Winqvist et al (Cancer Res 55: 2660-2664) have indicated that a survival factor gene is located in band 11q23, and that the highly informative microsatellite polymorphism at(More)
We studied the validity of the aphasia item of a widely used stroke scale - the Scandinavian Stroke Scale (SSS) - in discriminating between aphasia and normal language function in 33 stroke patients of an acute stroke unit. They were assessed by a nurse using the aphasia item from the SSS and by a speech and language therapist carrying out a full evaluation(More)