Knut A Engedal

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BACKGROUND Sequence variants, including the ε4 allele of apolipoprotein E, have been associated with the risk of the common late-onset form of Alzheimer's disease. Few rare variants affecting the risk of late-onset Alzheimer's disease have been found. METHODS We obtained the genome sequences of 2261 Icelanders and identified sequence variants that were(More)
OBJECTIVE To evaluate the long-term clinical efficacy and safety of donepezil versus placebo over 1 year in patients with mild to moderate AD. METHODS Patients (n = 286; mean age, 72.5 years) with possible or probable AD from five Northern European countries were randomized to receive either donepezil (n = 142; 5 mg/day for 28 days, followed by 10 mg/day)(More)
BACKGROUND Psychiatric and behavioural symptoms in dementia are associated with a range of negative outcomes, including institutional placement and the widespread use of psychotropic drugs in spite of limited evidence for their efficacy. AIMS To determine the prevalence of psychiatric and behavioural symptoms and the pattern of psychotropic drug(More)
OBJECTIVES To study how well the scoring on each item of the MMSE relates to the sum-score when the purpose is to identify persons with cognitive impairment, and to identify an equally effective subset of MMSE items for predicting cognitive impairment. DESIGN Retrospective survey of MMSE data for 850 elderly. SETTING A variety of clinical settings. (More)
We reanalyzed and compared current prevalence estimates of Alzheimer's disease in Europe. Studies characterized as follows qualified for comparison: dementia defined by the Diagnostic and Statistical Manual for Mental Disorders, 3rd edition, or equivalent criteria; Alzheimer's disease diagnosed by the National Institute of Neurological and Communicative(More)
BACKGROUND Psychiatric symptoms and behavioral disturbances are highly prevalent in the residents of nursing homes. The Neuropsychiatric Inventory (NPI) is a commonly used scale for the assessment of such symptoms in diverse settings. We have conducted a study of the reliability and the validity of the Norwegian version of the NPI nursing home version(More)
OBJECTIVE The purpose of this study was to determine the predictive power of sonographic tumor descriptors in the differentiation of fibroadenoma from invasive ductal carcinoma of the breast. SUBJECTS AND METHODS Three hundred thirty-six tumors (142 fibroadenomas and 194 invasive ductal carcinomas) of the breast diagnosed using sonography were(More)
OBJECTIVE To characterize the psychosocial burden on spouses living with the elderly suffering from mild dementia, stroke and Parkinson's disease, and to identify patient characteristics associated with it. Materials and methods Data on patient-spouse couples came from three studies of patients with stroke (36 couples), mild dementia (92 couples) and(More)
BACKGROUND In geriatric psychiatry assessment scales are often used in clinical praxis in the diagnostic work-up of mental disorders. AIM To assess whether the state part of the STAI is useful as a case-finding instrument of mental disorders. MATERIALS AND METHOD Data came from 70 non demented geriatric in-patients in stable clinical condition. Mean age(More)
AIM To study quality of life among the elderly with dementia in institutions. METHODS Patients above 60 years with dementia, 82 in nursing home and 74 in departments of geriatric psychiatry, were included. They were assessed with the Quality of Life in Late-Stage Dementia (QUALID); the Self-Maintenance scale, Mini Mental State Examination (MMSE) and(More)