Knud Stenild Christensen

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BACKGROUND Preclinical studies have indicated that angiogenic growth factors can stimulate the development of collateral arteries, a concept called "therapeutic angiogenesis." The objectives of this phase 1 clinical trial were (1) to document the safety and feasibility of intramuscular gene transfer by use of naked plasmid DNA encoding an endothelial cell(More)
BACKGROUND Bacterial artificial chromosome (BAC) libraries continue to be invaluable tools for the genomic analysis of complex organisms. Complemented by the newly and fast growing deep sequencing technologies, they provide an excellent source of information in genomics projects. RESULTS Here, we report the construction and characterization of the(More)
A 62-year-old woman with distal renal tubular acidosis (RTA) and hypokalemic muscle paralysis is described. As neither the history nor the clinical examination can differentiate between hypokalemic paralysis caused by RTA and that of familial hypokalemic paralysis, and because the emergency as well as prophylactic treatment of the two disorders are quite(More)
Association of MITF gene with hearing and pigmentation phenotype in Hedlund white American mink (Neovison vison). Microphthalmia-associated transcription factor (MITF) is an important regulatory factor involved in the migration of melanocytes during embryonic development. Similar to other described species, in the American mink too, the MITF gene seems to(More)
BACKGROUND Peripheral nerve sheath tumors (PNSTs) are frequently found in Danish cattle at slaughter. Bovine PNSTs share several gross and histopathological characteristics with the PNSTs in humans with heritable neurofibromatosis syndromes. The aim of the present study was to investigate a possible hereditary disposition to PNSTs in dairy cattle by(More)
BACKGROUND Bovine renal lipofuscinosis (BRL) is an incidental finding in cattle at slaughter. Condemnation of the kidneys as unfit for human consumption was until recently considered the only implication of BRL. Recent studies have indicated a negative influence on the health of affected animals. The present study investigated the prevalence, genetics and(More)
In this report we present the results of the analysis of approximately 2.7 Mb of genomic information for the American mink (Neovison vison) derived through BAC end sequencing. Our study, which encompasses approximately 1/1000th of the mink genome, suggests that simple sequence repeats (SSRs) are less common in the mink than in the human genome, whereas the(More)
Recently fibroblasts of many mammalian species have been reprogrammed to pluripotent state using overexpression of several transcription factors. This technology allows production of induced pluripotent stem (iPS) cells with properties similar to embryonic stem (ES) cells. The completeness of reprogramming process is well studied in such species as mouse(More)
Correspondence Bone transport of the tibia with a motorized intramedullary lengthe­ ning nail — a case report Open Access-This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited. Sir–We read with(More)
BACKGROUND A pig phenotype characterized by juvenile hairlessness, thin skin and age dependent lung emphysema has been discovered in a Danish pig herd. The trait shows autosomal co-dominant inheritance with all three genotypes distinguishable. Since the phenotype shows resemblance to the integrin beta6 -/- knockout phenotype seen in mice, the two genes(More)