Knox Cartwright

Learn More
Advanced glycosylation end products (AGEs) form spontaneously from glucose-derived Amadori products and accumulate on long-lived tissue proteins. AGEs have been implicated in the pathogenesis of several of the complications of aging and diabetes, including atherosclerosis and renal disease. With the use of recently developed AGE-specific antibodies, an(More)
Toxic effects of hyperglycemia-induced advanced glycosylated end products (AGEs) may explain some vasculopathic complications of diabetes. Aminoguanidine, a known inhibitor of AGE formation, was administered by gavage to Sprague-Dawley streptozotocin-induced diabetic rats made azotemic by surgical reduction of renal mass. All rats became hyperglycemic.(More)
The dramatic variation in the composition of a brine pond in Antarctica is a seasonal phenomenon. The phase relations of salts in solution are such that hydrologic conditions and temperature determine composition during the austral summer. Temperature is the primary determinant of composition during the winter.
To study the distribution and predominant orientations of fibrillar collagen at different depths throughout the entire thickness of the human cornea. This information will form the basis of a full three-dimensional reconstruction of the preferred orientations of corneal lamellae. Femtosecond laser technology was used to delaminate the central zones of five(More)
  • 1