Kleoniki Lyroudia

Learn More
The evaluation of fluorescent in situ hybridization (FISH) images is one of the most widely used methods to determine Her-2/neu status of breast samples, a valuable prognostic indicator. Conventional evaluation is a difficult task since it involves manual counting of dots in multiple images. In this paper, we present a multistage algorithm for the automated(More)
HER2-positive breast cancer is characterized by aggressive growth and poor prognosis. Women with metastatic breast cancer with over-expression of HER2 protein or excessive presence of HER2 gene copies are potential candidates for Herceptin (Trastuzumab) targeted treatment that binds to HER2 receptors on tumor cells and inhibits tumor cell growth.(More)
The purpose of this study was to evaluate the suitability of a digital radiograph registration and subtraction software for a sensitive and reliable assessment of the progress of chronic apical periodontitis. Ninety cases of teeth with chronic apical periodontitis have been studied. In each case, a preoperative radiograph was taken, root canals were(More)
AIM AND METHODOLOGY Two cases of internal tooth resorption were examined. A mandibular premolar and a mandibular canine were studied after they were extracted using radiographs, a stereomicroscope (SM) and a scanning electron microscope (SEM). Lastly, 3D images of the sectioned teeth were obtained(3D). RESULTS Radiographically, internal root resorption(More)
In this paper, a new high-resolution model of a virtual human head is introduced, aiming to build an educational tool for anatomy studies of the head, oral/nasal cavities and teeth. The human head model is based on anatomical data provided by Visible Human Project. Firstly, anatomical structures' contours were extracted on head slices in a semi-automatic(More)
The purpose of this study was the application of both digital three-dimensional image processing and virtual reality techniques in endodontics. Three-dimensional volume representations of 2 teeth from each tooth category, 16 teeth in total, have been reconstructed. All teeth were embedded in polyester resin, and serial cross-sections 0.75-mm thick were(More)
As a result of rapid advances in genome sequencing, the pace of discovery of new protein sequences has surpassed that of structure and function determination by orders of magnitude. This is also true for metal-binding proteins, that is, proteins that bind one or more metal atoms necessary for their biological function. While metal binding site geometry and(More)
Fluorescent in-situ hybridization (FISH) and immunohistochemistry (IHC) constitute a pair of complimentary techniques for detecting gene amplification and overexpression, respectively. The advantages of IHC include relatively cheap materials and high sample durability, while FISH is the more accurate and reproducible method. Evaluation of FISH and IHC(More)
This paper introduces, a virtual teeth drilling system named Virtual Dental Patient designed to aid dentists in getting acquainted with the teeth anatomy, the handling of drilling instruments and the challenges associated with the drilling procedure. The basic aim of the system is to be used for the training of dental students. The application features a 3D(More)