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The influence of a finite volume of ions and orientational ordering of water Langevin dipoles on the dielectric permittivity profile in the vicinity of charged surface is studied theoretically via a numerical solution of the modified Poisson-Boltzmann equation. It is shown that the dielectric permittivity profile close to the charged surface is mainly(More)
We calculate the membrane-mediated interaction between two cylindrical inclusions in a symmetric lipid bilayer. Our theory takes two contributions to the free energy into account, the elastic behavior of the membrane and the conformational restrictions that the flexible hydrocarbon chains of the lipids experience in the vicinity of a rigid inclusion. The(More)
In biological systems, charged membrane surfaces are surrounded by charged molecules such as electrolyte ions and proteins. Our recent experiments in the systems of giant phospholipid vesicles indicated that some of the blood plasma proteins (macro-ions) may promote adhesion between equally charged membrane surfaces. In this work, theory was put forward to(More)
DNA is stored in vivo in a highly compact, so-called condensed phase, where gene regulatory processes are governed by the intricate interplay between different states of DNA compaction. These systems often have surprising properties, which one would not predict from classical concepts of dilute solutions. The mechanistic details of DNA packing are essential(More)
A simple statistical mechanical approach is applied to calculate the profile of the density of the number of particles and the profile of the electrostatic potential of an electric double layer formed by a charged cylindrical surface in contact with electrolyte solution. The finite size of particles constituting the electrolyte solution is considered by(More)
Divalent cations, i.e., calcium, magnesium, and others, are able to enhance the ability of DNA to interact with membranes that are composed of zwitterionic lipids such as phosphatidylcholine. The resulting condensed complexes offer potential applications as nontoxic gene delivery vehicles. The present study suggests a generic theoretical model to describe(More)
We observed monoclonal antibody mediated coalescence of negatively charged giant unilamellar phospholipid vesicles upon close approach of the vesicles. This feature is described, using a mean field density functional theory and Monte Carlo simulations, as that of two interacting flat electrical double layers. Antibodies are considered as spherical(More)
A membrane inclusion can be defined as a complex of protein or peptide and the surrounding significantly distorted lipids. We suggest a theoretical model that allows for the estimation of the influence of membrane inclusions on the curvature elastic properties of lipid membranes. Our treatment includes anisotropic inclusions whose energetics depends on(More)
A theoretical model of a two-component bilayer membrane was used in order to describe the influence of anisotropic membrane inclusions on shapes of membrane daughter micro and nano vesicles. It was shown that for weakly anisotropic inclusions the stable vesicle shapes are only slightly out-of-round. In contrast, for strongly anisotropic inclusions the(More)