Klaziena Politiek

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We retrospectively reviewed patient records between January 2000 and 16 December 2015 (data lock). Patients were identified according to the International Classification of Disease (10th edition) diagnoses L20, L23-25, and L30. We included adult patients with severe chronic hand eczema who were treated with azathioprine. Patients with concomitant mild(More)
DEAR EDITOR, Methotrexate is prescribed off-label for atopic dermatitis. Some clinical studies of methotrexate treatment in atopic dermatitis have demonstrated effectiveness, although the number of patients was small and the treatment and follow-up periods were relatively short. Therefore, we conducted an analysis of drug survival for methotrexate in a(More)
BACKGROUND Long-term data of ciclosporin A (CsA) treatment in daily practice in patients with severe atopic dermatitis (AD) are lacking. OBJECTIVES To perform a detailed analysis of drug survival, which is the length of time a patient continues to take a drug, for CsA in a long-term daily practice cohort of patients with AD. The secondary objective was to(More)
The individual burden of disease in hand eczema patients is considerable. However, little is known about the socio-economic impact of this disease. The aims of this review were to evaluate the literature on cost-of-illness in hand eczema, and to compose a checklist for future use. The literature was retrieved from the MEDLINE and EMBASE databases up to(More)
DEAR EDITOR, Results from clinical studies indicate that azathioprine (AZA) and enteric-coated mycophenolate sodium (EC-MPS) are safe and potent drugs for the treatment of atopic dermatitis (AD). However, published data from large groups of nonselected patients are nonexistent, which hampers generalization to daily practice. In addition, head-to-head trials(More)
There is uncertainty about the risk of developing non-melanoma skin cancer (NMSC), including basal cell carcinoma and squamous cell carcinoma (SCC), in patients with atopic dermatitis (AD) treated with oral immunosuppressive drugs. A total of 557 patients with AD treated with these drugs in the University Medical Center Utrecht and Groningen, the(More)
Hand eczema is a common occupational skin disease in healthcare workers. This is often the result of repeated contact with irritants, such as water; however, contact allergy can also be the underlying cause. In this report, we describe a patient with occupational hand eczema, caused by contact allergy to 1-propanol (CAS no. 71-23-8; synonyms n-propanol and(More)
Acitretin has been used off-label for years to treat chronic hand eczema, but acitretin is less often prescribed as alitretinoïne was approved. This study evaluates both retinoids in a daily practice cohort of patients with severe chronic hand eczema in terms of drug survival and reasons for discontinuation. Patients using alitretinoin or acitretin between(More)