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Astroglial metabolic networks sustain hippocampal synaptic transmission.

• Nathalie Rouach, Annette Koulakoff, Verónica Abudara, Klaus Willecke, Christian Giaume
• Science
• 2008

Astrocytes provide metabolic substrates to neurons in an activity-dependent manner. However, the molecular mechanisms involved in this function, as well as its role in synaptic transmission, remain… (More)

Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells

• Claudia Elfgang, Reiner Eckert, +5 authors Klaus Willecke
• The Journal of cell biology
• 1995

DNAs coding for seven murine connexins (Cx) (Cx26, Cx31, Cx32, Cx37, Cx40, Cx43, and Cx45) are functionally expressed in human HeLa cells that were deficient in gap junctional communication. We… (More)

The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus.

• Anke Wallraff, Rüdiger Köhling, Uwe F Heinemann, Martin Theis, Klaus Willecke, Christian Steinhäuser
• The Journal of neuroscience : the official…
• 2006

Astrocytic gap junctions have been suggested to contribute to spatial buffering of potassium in the brain. Direct evidence has been difficult to gather because of the lack of astrocyte-specific gap… (More)

Gap junctions and the connexin protein family.

• Goran Söhl, Klaus Willecke
• Cardiovascular research
• 2004

Gap junctions (Gj) form conduits between adjacent cells that are composed of connexin (Cx) protein subunits and allow direct intercellular communication. To date, the connexin gene family comprises… (More)

Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture.

• Jorge E Contreras, Helmut A Sánchez, +6 authors Juan C Sáez
• Proceedings of the National Academy of Sciences…
• 2002

Rat cortical astrocytes in pure culture are functionally coupled to neighboring cells via connexin (Cx) 43 gap junctions under ordinary conditions. Small fluorescent molecules such as Lucifer yellow… (More)

Expression and functions of neuronal gap junctions

• Goran Söhl, Stephan Maxeiner, Klaus Willecke
• Nature Reviews Neuroscience
• 2005

Gap junctions are channel-forming structures in contacting plasma membranes that allow direct metabolic and electrical communication between almost all cell types in the mammalian brain. At least 20… (More)

Accelerated hippocampal spreading depression and enhanced locomotory activity in mice with astrocyte-directed inactivation of connexin43.

• Martin Theis, Regina Jauch, +12 authors Klaus Willecke
• The Journal of neuroscience : the official…
• 2003

Using a human glial fibrillary acidic protein (hGFAP) promoter-driven cre transgene, we have achieved efficient inactivation of a floxed connexin43 (Cx43) gene in astrocytes of adult mice. The loss… (More)

hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo.

• Lang Zhuo, Martin Theis, Ikuri Alvarez-Maya, Michael B Brenner, Klaus Willecke, Albee Messing
• Genesis
• 2001

With the goal of performing astrocyte-specific modification of genes in the mouse, we have generated a transgenic line expressing Cre recombinase under the control of the human glial fibrillary… (More)

Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release.

• Magalie A. Ravier, Martin Gueldenagel, +7 authors Paolo Meda
• Diabetes
• 2005

Normal insulin secretion requires the coordinated functioning of beta-cells within pancreatic islets. This coordination depends on a communications network that involves the interaction of beta-cells… (More)

Targeted Ablation of Connexin26 in the Inner Ear Epithelial Gap Junction Network Causes Hearing Impairment and Cell Death

• Martine Cohen-Salmon, Thomas Ott, +8 authors Christine Petit
• Current Biology
• 2002

Mutations in the gene encoding the gap junction protein connexin26 (Cx26) are responsible for the autosomal recessive isolated deafness, DFNB1, which accounts for half of the cases of prelingual… (More)

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