Klaus Pugner

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OBJECTIVE The characteristic joint damage and disability of rheumatoid arthritis (RA) increase slowly over 10-20 yr. Although it is generally believed that persisting inflammatory synovitis causes joint damage and subsequent disability, the strength of their relationship has not been systematically evaluated. This review describes their progression and(More)
BACKGROUND Several factors are thought to influence resource use and costs in treating schizophrenia. AIMS To assess the relative impact of non-adherence and other factors associated with resource use and costs incurred by people with schizophrenia. METHOD Secondary analyses were made of data from a 1994 national survey of psychiatric morbidity among(More)
This study explored general practitioner (GP) perceptions of use of treatments to manage hyperlipidaemia and their cost implications. GPs recognized different levels of coronary heart disease (CHD) risk, but were not always aware of which were major factors. Most were unfamiliar with published guidelines on managing hyperlipidaemia, and were likely to(More)
Data of prescribing practices for antipsychotics are of great interest with respect to quality of care. Consequently, we analysed all prescriptions under the statutory health insurance redeemed at pharmacies in Southern Germany between July 1999 and December 2001. The database covers prescriptions for approximately 25 million people. Up to 6% of the(More)
OBJECTIVES To review the literature on the measurable direct and indirect costs of rheumatoid arthritis (RA) in industrialized countries from a societal perspective and to develop a template for international use. METHODS A literature search using MEDLINE and other sources identified 153 relevant published articles, press releases, and so forth on the(More)
PURPOSE The objective of this study was to quantify rates of adverse events in a high-risk multi-morbid population of institutionalized patients with Alzheimer's disease (AD). METHODS We conducted a retrospective cohort study among nursing home residents diagnosed with AD and psychosis during January 1998 to October 1999. Using the Medicare Minimum Data(More)
Bedwetting is a common complaint, affecting approximately 10% of 7-year old children in the developed world and causing an economic drain on society. Not only is the cost of nocturnal enuresis borne by the families, but also by national health services and state health insurance. Although previous studies have examined the direct costs of nocturnal(More)
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