Klaus-Peter Ossenkopp

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Clinical observations suggest that certain gut and dietary factors may transiently worsen symptoms in autism spectrum disorders (ASD), epilepsy and some inheritable metabolic disorders. Propionic acid (PPA) is a short chain fatty acid and an important intermediate of cellular metabolism. PPA is also a by-product of a subpopulation of human gut(More)
A substantial body of evidence has accumulated showing that exposure to electromagnetic fields (EMFs) affects pain sensitivity (nociception) and pain inhibition (analgesia). Consistent inhibitory effects of acute exposures to various EMFs on analgesia have been demonstrated in most studies. This renders examinations of changes in the expression of analgesia(More)
The vestibular system has been suggested to participate in spatial navigation, a function ascribed to the hippocampus. Vestibular stimulation during spatial navigation activates a hippocampal theta rhythm (4-10 Hz), which may enhance spatial processing and motor response. We hypothesize that a cholinergic, atropine-sensitive theta is generated during(More)
The endogenous cannabinoid system plays a vital role in the control of nausea and emesis. Because of the rapid breakdown and hydrolysis of endocannabinoids, such as anandamide, the therapeutic effects may be enhanced by prolonging their duration of action. The present experiment evaluated the potential of various doses of URB597, a fatty acid amide(More)
Following one or more chemotherapy treatments, many patients report that they experience anticipatory nausea. This phase of nausea has been interpreted as a classically conditioned response where a conditional association develops between the contextual clinic cues and the nausea and/or vomiting that developed following treatment. Although rats do not(More)
In two experiments albino rats were injected i.p. with various doses of taurine and their subsequent behavior in an open-field apparatus was observed. Increasing doses of taurine significantly decreased ambulation levels, increased latency scores, and increased thigmotaxis (‘wall-hugging’ behavior). In general, 50 mg/kg or more of taurine was required to(More)
Administration of bacterial agents, such as muramyl dipeptide (MDP) or lipopolysaccharide (LPS), induces a number of illness symptoms including decreased locomotor activity and weight loss. This study provides a detailed multivariate assessment of the effects of repeated exposures of various doses of MDP and LPS, alone and in combination, on various aspects(More)
Sensitization of dopaminergic neural reward circuits has been hypothesized to be involved in the development of drug addiction. Highly palatable foods activate these same brain areas, specifically the nucleus accumbens. In this study, the effects of a highly palatable food (sucrose) on these circuits were investigated using the dopamine D(2)/D(3) receptor(More)
Administration of the bacterial cell wall component, lipopolysaccharide (LPS), stimulates the immune and endocrine systems inducing an acute phase of sickness and stress responses in adult and neonatal rats. Neonatal LPS exposure has been shown to alter a variety of behavioural and physiological processes in the adult animal. Early developmental stress,(More)
Environmental, dietary, and gastrointestinal factors may contribute to autism spectrum disorders (ASD). Propionic acid (PPA) is a short chain fatty acid, a metabolic end-product of enteric bacteria in the gut, and a common food preservative. Recent evidence indicates that PPA can cause behavioral abnormalities and a neuroinflammatory response in rats.(More)