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OBJECTIVE To assess the efficacy and safety of the novel angiotensin II antagonist olmesartan medoxomil in patients with mild to moderate essential hypertension, using a meta-analysis of the combined database from seven US and European clinical trials. DESIGN Studies were randomized, double-blind, placebo-controlled and dose-finding (2.5-80 mg), with(More)
BACKGROUND Drugs that block the renin-angiotensin system represent one of the most significant therapeutic interventions available for the treatment of hypertension. The angiotensin II receptor antagonists (AIIRAs), also known as sartans, are one such class of drugs that block the effects of angiotensin II by antagonizing the angiotensin II type 1 receptor.(More)
Regression of hypertensive left ventricular hypertrophy (LVH) is associated with improved prognosis. The aim of this trial was to compare the effects of irbesartan versus atenolol on LVH in subjects with essential hypertension. Because electrocardiographic and echocardiographic parameters of LVH carry disparate prognostic information, both methods were(More)
OBJECTIVE To compare the relative efficacy and safety of olmesartan medoxomil (OM) with atenolol, captopril and losartan in phase III trials on mild to severely hypertensive patients. DESIGN Multi-centre, randomized, double-blind, parallel group, with dose-titration studies lasting 12 or 24 weeks. METHODS Two studies respectively compared 10 mg OM once(More)
The therapeutic profile of olmesartan medoxomil, which is a recently developed angiotensin II (A II) receptor blocker, has been compared with four commonly used antihypertensive therapeutic drugs (atenolol, captopril, felodipine and losartan) in five separate multicentre, randomised, double-blind, parallel-group, phase III trials. The trials were designed(More)
OBJECTIVE The effects of severe and moderate sodium restriction on blood pressure, neurohormonal activity and serum lipids were studied in non-obese normotensive adults. METHODS In the first part of the study, 163 subjects were randomly assigned to a diet of 20 or 300 mmol/day sodium for 1 week each. In the second part, 25 subjects were given a diet of 85(More)
OBJECTIVE To compare the antihypertensive efficacy of olmesartan medoxomil with that of candesartan cilexetil after 1, 2 and 8 weeks of treatment. DESIGN AND SETTING Randomised, double-blind, parallel-group study conducted at 44 centres in Germany, Poland and the Czech Republic. PATIENTS 643 patients (aged 19-86 years) with mainly mild-to-moderate(More)
Opioid delta receptors seem to be involved in blood pressure regulation of spontaneously hypertensive rats (SHR), possibly by an interaction with the sympathetic nervous system. In the present study the effect of four weeks' chronic delta receptor antagonism with ICI 154 129 on development of blood pressure was evaluated in young SHR. Contents of adrenaline(More)
Blood pressure responses to 1 week of low-salt (20 mmol sodium/d) and high-salt (300 mmol sodium/d) intake were investigated in a single-blind randomized study in 163 white, nonobese normotensive subjects (65 women and 98 men; mean age, 38 +/- 1.2 years). The individuals were classified as salt sensitive when mean arterial blood pressure rose by at least 5(More)