Klaus-Malte Flechtner

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BACKGROUND Smooth pursuit eye movement (SPEM) dysfunctions are considered a biological marker for schizophrenia and have been studied widely. In contrast, saccadic eye movements have received less attention, although disturbances have been described previously. Basic neurophysiologic parameters of saccades in schizophrenics, especially in unmedicated(More)
BACKGROUND Smooth pursuit eye movement dysfunctions are considered a biological indicator for vulnerability to schizophrenia. This study examines test-retest stability of specific eye movement variables such as velocity gain and different saccadic categories. METHODS Smooth pursuit eye movements of 27 schizophrenic patients and 30 patients with major(More)
BACKGROUND Smooth pursuit eye movement (SPEM) dysfunction is considered to be a promising candidate for a biological marker for genetic vulnerability to schizophrenia. There are conflicting findings regarding the question of what is exactly dysfunctional in SPEM dysfunction and what component of eye movements is really specific to schizophrenia. The purpose(More)
During a standardized visuomotor task, eye blinking, a possible parameter of central dopaminergic activity, was studied in 18 previously medicated and eight drug-naive schizophrenic in-patients in the acute state and during remission. Whereas schizophrenics executed the visuomotor task with the same precision as age- and sex-matched normal control subjects(More)
Eye blinks were investigated during a standardized visuomotor task in 15 drug-naive schizophrenic inpatients (8 men and 7 women) and 15 age- and gender-matched healthy volunteers. Whereas the schizophrenics demonstrated the same precision as normal controls in executing the visuomotor task, their mean blink rate was markedly increased (16.2 +/- 10.8 versus(More)
Over the last 30-40 years the reform of psychiatric care in many countries has led to deinstitutionalization and treatment of many patients in community psychiatric services. There is an ongoing discussion on whether this process may lead to a higher suicide rate. There are only a few studies addressing this issue, and empirical data are scarce. Several(More)
Severe neuropsychiatric manifestations in mixed connective tissue disease (MCTD) are thought to be quite rare. We report an unusual case of MCTD with recurrent optic neuropathy and transverse myelopathy suggestive of a relapsing-remitting demyelinating disorder. Symptoms responded dramatically to a treatment with plasmapheresis and immunosuppressive(More)
Smooth pursuit eye movement (SPEM) dysfunctions in major affective disorder patients have been reported to be associated with lithium treatment. We report that SPEM of 13 healthy volunteers, either taking lithium (n = 7) or placebo (n = 6), were not significantly impaired by lithium. This could point to a pathophysiologic difference between affective(More)
Subthreshold symptoms in schizophrenia can be prodromal signs of a psychotic relapse. In people without schizophrenia, similar symptoms may indicate the presence of disorders termed schizophrenia spectrum disorders. Subthreshold schizophrenia-like symptoms may indicate a genetically transmitted higher proneness to schizophrenia. Such a higher liability to(More)
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